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dc.contributor.author
Stanganelli, Carmen
dc.contributor.author
Torres, Davi Coe
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Ortega, Claudia
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Sotelo, Natalia
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Márquez, María Elena
dc.contributor.author
Segges, Priscilla
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Muniz, Maria Tereza C.
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Bigni, Ricardo S.
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Campregher, Paulo V.
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Sabino, Adriano
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Perez Gomes, Caio
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Lopes Ferrari de Chauffaille, María Lourdes
dc.contributor.author
Arrais Rodrigues, Celso
dc.contributor.author
Yamamoto, Mihoko
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Abdelhay, Eliana
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Cabrera, Juana
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Deglesne, Pierre Antoine
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López, José Luis
dc.contributor.author
Galvano, Camila
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Krzywinski, Andrea Mariel
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Bezares, Raimundo F.
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Lang, Cecilia
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Zanella, Lorena
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Agriello, Evangelina Edith
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Cabrejo, María
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Gabús, Raúl
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Dighiero, Guillermo
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Oppezzo, Pablo
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Hassan, Rocio
dc.contributor.author
Slavutsky, Irma Rosa
dc.date.available
2023-08-07T15:51:17Z
dc.date.issued
2019-08
dc.identifier.citation
Stanganelli, Carmen; Torres, Davi Coe; Ortega, Claudia; Sotelo, Natalia; Márquez, María Elena; et al.; Distinctive IGHV gene usage and stereotyped receptors in South American patients with chronic lymphocytic leukemia; John Wiley & Sons Ltd; Hematological Oncology; 37; 5; 8-2019; 644-648
dc.identifier.issn
0278-0232
dc.identifier.uri
http://hdl.handle.net/11336/207222
dc.description.abstract
The IGHV (immunoglobulin heavy-chain variable region) gene mutational status is one of the most important prognostic factors in chronic lymphocytic leukemia (CLL). At present, there is limited information about CLL patients from South American countries. We have evaluated the IGHV mutational status, gene usage and stereotyped BCRs in CLL patients from four South American countries, in a multi-institutional collaborative study. Results were correlated with genomic aberrations and clinical prognostic factors of the disease. Our cohort included 900 unselected CLL patients from Argentina (362), Brazil (358), Uruguay (101) and Venezuela (79). The whole series showed 52.6% M-CLL and 47.4% UM-CLL patients. IGHV3 family was prevalent (42.9%), while IGHV4 and IGHV1 showed the same frequency (24%). IGHV1-69 gene was the most frequently used (12.2%), followed by IGHV4-34 and IGHV3-23. IGHV1-69 was the most frequent rearrangement in Brazilian patients, Uruguayan series showed the highest frequencies of IGHV3-7 and IGHV3-23, and IGHV3-21 was preferentially expressed in Venezuelan cohort. Stereotyped BCRs were present in 14% of cases, mostly associated with an UM state (69%); 66% of them belong to major subsets. In the whole series, subset #4 was the most frequently found, followed by subsets #1 and #2. Subset #1 was the largest in Brazil, subset #2 in Argentina, whereas subset #4 was the most frequently found in Uruguay and Venezuela. IGHV4-34 gene showed a higher proportion of stereotypy in Argentina and Uruguay with significant differences between Brazil and Uruguay (p=0.007). One potential novel subset was found. Association between complex karyotypes, ≥2 FISH alterations, trisomy 12 and 11q22 deletion with UM-IGHV state (p<0.04) was observed. Advanced clinical stage, higher whole blood count and β2microglobulin levels (p<0.03) as well as a short time to first treatment (p=0.0001) were also associated to UM-CLL patients. Our results show interesting differences between CLL patients from different South American countries, reflecting the role of genetic background and environmental factors in CLL pathogenesis in our subcontinent.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CHRONIC LYMPHOCYTIC LEUKEMIA
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IGHV
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STEREOTYPED RECEPTORS
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FISH
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Genética Humana
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Distinctive IGHV gene usage and stereotyped receptors in South American patients with chronic lymphocytic leukemia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-05-30T11:00:05Z
dc.journal.volume
37
dc.journal.number
5
dc.journal.pagination
644-648
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Stanganelli, Carmen. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
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Fil: Torres, Davi Coe. Instituto Nacional del Cáncer; Brasil
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Fil: Ortega, Claudia. Instituto Pasteur de Montevideo; Uruguay
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Fil: Sotelo, Natalia. Instituto Pasteur de Montevideo; Uruguay
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Fil: Márquez, María Elena. Instituto Venezolano de Investigaciones Científicas; Venezuela
dc.description.fil
Fil: Segges, Priscilla. Instituto Nacional del Cáncer; Brasil
dc.description.fil
Fil: Muniz, Maria Tereza C.. Universidade Federal de Pernambuco; Brasil
dc.description.fil
Fil: Bigni, Ricardo S.. Instituto Nacional del Cáncer; Brasil
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Fil: Campregher, Paulo V.. Universidade Estadual de Campinas; Brasil
dc.description.fil
Fil: Sabino, Adriano. Universidade Federal de Minas Gerais; Brasil
dc.description.fil
Fil: Perez Gomes, Caio. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Lopes Ferrari de Chauffaille, María Lourdes. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Arrais Rodrigues, Celso. Universidade Federal de Sao Paulo; Brasil
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Fil: Yamamoto, Mihoko. Universidade Federal de Sao Paulo; Brasil
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Fil: Abdelhay, Eliana. Instituto Nacional del Cáncer; Brasil
dc.description.fil
Fil: Cabrera, Juana. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
dc.description.fil
Fil: Deglesne, Pierre Antoine. Instituto Venezolano de Investigaciones Científicas; Venezuela
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Fil: López, José Luis. Banco Municipal de Sangre; Venezuela
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Fil: Galvano, Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
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Fil: Krzywinski, Andrea Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
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Fil: Bezares, Raimundo F.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina
dc.description.fil
Fil: Lang, Cecilia. No especifíca;
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Fil: Zanella, Lorena. No especifíca;
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Fil: Agriello, Evangelina Edith. No especifíca;
dc.description.fil
Fil: Cabrejo, María. No especifíca;
dc.description.fil
Fil: Gabús, Raúl. Hospital Maciel, Montevideo; Uruguay
dc.description.fil
Fil: Dighiero, Guillermo. Instituto Pasteur de Montevideo; Uruguay
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Fil: Oppezzo, Pablo. Instituto Pasteur de Montevideo; Uruguay
dc.description.fil
Fil: Hassan, Rocio. Instituto Nacional del Cáncer; Brasil
dc.description.fil
Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.journal.title
Hematological Oncology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/hon.2661
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/hon.2661
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