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dc.contributor.author
Abdelraheem, Eman
dc.contributor.author
Thair, Benjamin
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Fernández Varela, Romina Noelia
dc.contributor.author
Jockmann, Emely
dc.contributor.author
Popadić, Désirée
dc.contributor.author
Hailes, Helen C.
dc.contributor.author
Ward, John M.
dc.contributor.author
Iribarren, Adolfo Marcelo
dc.contributor.author
Lewkowicz, Elizabeth Sandra
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Andexer, Jennifer N.
dc.contributor.author
Hagedoorn, Peter Leon
dc.contributor.author
Hanefeld, Ulf
dc.date.available
2023-08-03T12:12:48Z
dc.date.issued
2022-09
dc.identifier.citation
Abdelraheem, Eman; Thair, Benjamin; Fernández Varela, Romina Noelia; Jockmann, Emely; Popadić, Désirée; et al.; Methyltransferases: Functions and Applications; Wiley VCH Verlag; Chembiochem; 23; 18; 9-2022; 1-19
dc.identifier.issn
1439-4227
dc.identifier.uri
http://hdl.handle.net/11336/206705
dc.description.abstract
In this review the current state-of-the-art of S-adenosylmethionine (SAM)-dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in synthesis are introduced with different supply and regeneration approaches evaluated. The use of SAM analogues are also described. Finally O-, N-, C- and S-MTs, their synthetic applications and potential for compound diversification is given.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley VCH Verlag
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
BIOCATALYSIS
dc.subject
ENZYMES
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METHYLTRANSFERASES
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S-ADENOSYL-L-METHIONINE
dc.subject.classification
Química Orgánica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Methyltransferases: Functions and Applications
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-08-02T17:55:46Z
dc.journal.volume
23
dc.journal.number
18
dc.journal.pagination
1-19
dc.journal.pais
Alemania
dc.journal.ciudad
Weinheim
dc.description.fil
Fil: Abdelraheem, Eman. Delft University of Technology; Países Bajos
dc.description.fil
Fil: Thair, Benjamin. Colegio Universitario de Londres; Reino Unido
dc.description.fil
Fil: Fernández Varela, Romina Noelia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Área Química. Laboratorio de Biotransformaciones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Jockmann, Emely. Albert Ludwigs University of Freiburg; Alemania
dc.description.fil
Fil: Popadić, Désirée. Albert Ludwigs University of Freiburg; Alemania
dc.description.fil
Fil: Hailes, Helen C.. Colegio Universitario de Londres; Reino Unido
dc.description.fil
Fil: Ward, John M.. Colegio Universitario de Londres; Reino Unido
dc.description.fil
Fil: Iribarren, Adolfo Marcelo. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Área Química. Laboratorio de Biotransformaciones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Lewkowicz, Elizabeth Sandra. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Área Química. Laboratorio de Biotransformaciones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Andexer, Jennifer N.. Albert Ludwigs University of Freiburg; Alemania
dc.description.fil
Fil: Hagedoorn, Peter Leon. Delft University of Technology; Países Bajos
dc.description.fil
Fil: Hanefeld, Ulf. Delft University of Technology; Países Bajos
dc.journal.title
Chembiochem
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cbic.202200212
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/cbic.202200212
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