Artículo
ADAN: a database for prediction of protein–protein interaction of modular domains mediated by linear motifs
Encinar, J. A.; Fernández Ballester, G.; Sánchez Miguel, Ignacio Enrique
; Hurtado Gómez, E.; Stricher, F.; Beltrao, P.; Serrano, L.
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Fecha de publicación:
09/2009
Editorial:
Oxford University Press
Revista:
Bioinformatics (oxford, England)
ISSN:
1367-4803
e-ISSN:
1367-4811
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Motivation: Most of the structures and functions of proteome globular domains are yet unknown. We can use high-resolution structures from different modular domains in combination with automatic protein design algorithms to predict genome-wide potential interactions of a protein. ADAN database and related web tools are online resources for the predictive analysis of ligand–domain complexes. ADAN database is a collection of different modular protein domains (SH2, SH3, PDZ, WW, etc.). It contains 3505 entries with extensive structural and functional information available, manually integrated, curated and annotated with cross-references to other databases, biochemical and thermodynamical data, simplified coordinate files, sequence files and alignments. Prediadan, a subset of ADAN database, offers position-specific scoring matrices for protein–protein interactions, calculated by FoldX, and predictions of optimum ligands and putative binding partners. Users can also scan a query sequence against selected matrices, or improve a ligand–domain interaction.
Palabras clave:
Protein-Protein Interaction
,
Modular Domains
,
Linear Motifs
,
Database
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Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Encinar, J. A.; Fernández Ballester, G.; Sánchez Miguel, Ignacio Enrique; Hurtado Gómez, E.; Stricher, F.; et al.; ADAN: a database for prediction of protein–protein interaction of modular domains mediated by linear motifs; Oxford University Press; Bioinformatics (oxford, England); 25; 18; 9-2009; 2418-2424
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