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dc.contributor.author
Musso, Carlos Guido
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Cordoba, Juan P.
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Aroca Marinez, Gustavo
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Terrasa, Sergio Adrian
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Barriga Moreno, Adriana P.
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Lozano-Sanchez, Marcela
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Barón Alvarez, Rafael A.
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Gonzalez Torres, Henry
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Cantos, Joaquin
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Huespe, Iván
dc.date.available
2023-08-02T15:06:33Z
dc.date.issued
2022-12
dc.identifier.citation
Musso, Carlos Guido; Cordoba, Juan P.; Aroca Marinez, Gustavo; Terrasa, Sergio Adrian; Barriga Moreno, Adriana P.; et al.; Negative alactic base excess is reversed by hemoperfusion in septic patients; Giornale di Clinica Nefrologica e Dialisi; Giornale di Clinica Nefrologica e Dialisi; 34; 1; 12-2022; 122-124
dc.identifier.issn
2705-0076
dc.identifier.uri
http://hdl.handle.net/11336/206547
dc.description.abstract
Introduction: Gattinoni et al. have recently introduced a new parameter: the “alactic base excess” (ABE). ABE is equivalent to the number of strong acids, other than lactate, which are present in the plasma in abnormal concentrations, negative ABE being associated with higher mortality in sepsis. Hemoperfusion (HPF) is an extracorporeal procedure that involves the passage of blood through an adsorption cartridge, where solutes are removed by direct binding to the sorbent material. Then, it was decided to explore the influence of HPF on negative ABE value in sepsis.Materials and methods: Basal values of ABE, standard base excess (SBE), and lactate (mean, standard deviation [SD]) were obtained. The difference between these parameter values before and after four sessions of HPF (HA330) (delta value) was evaluated. Student’s t-test and Wilcoxon test were applied.Results: From 32 patients (age: 57±13) suffering from respiratory insufficiency secondary to COVID-19 who were treated with HPF in the critical care unit of Clinica de la Mujer, Bogotá (Colombia), 6 patients presented with metabolic acidosis with negative ABE value (‒2.7±1) with negative SBE (‒4.7±1) and high lactate serum value (2±0.7 mmol/L). Delta ABE, SBE, and lactate were: 7.7 (p = 0.005), 6.1 (p = 0.003), and 1.6 (p = NS), respectively. Thus, negative ABE was significantly reversed by HPF, since SBE value turned positive without significant change in lactate.Conclusion: Negative alactic parameter was significantly reversed by HPF in septic patients. It is necessary to carry out evaluations in larger groups to estimate their impact on clinical outcomes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Giornale di Clinica Nefrologica e Dialisi
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
ALACTIC BASE EXCESS
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HEMOPERFUSION
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SEPSIS
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Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Negative alactic base excess is reversed by hemoperfusion in septic patients
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-08-02T10:51:53Z
dc.journal.volume
34
dc.journal.number
1
dc.journal.pagination
122-124
dc.journal.pais
Italia
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dc.description.fil
Fil: Musso, Carlos Guido. Hospital Italiano; Argentina
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Fil: Cordoba, Juan P.. Universidad Simon Bolivar.; Venezuela
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Fil: Aroca Marinez, Gustavo. Universidad Simon Bolivar.; Venezuela
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Fil: Terrasa, Sergio Adrian. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Barriga Moreno, Adriana P.. Universidad Simon Bolivar.; Venezuela
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Fil: Lozano-Sanchez, Marcela. Universidad del Norte; Colombia
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Fil: Barón Alvarez, Rafael A.. Universidad del Norte; Colombia
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Fil: Gonzalez Torres, Henry. Universidad Simon Bolivar.; Venezuela
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Fil: Cantos, Joaquin. Universidad del Norte; Colombia
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Fil: Huespe, Iván. Hospital Italiano; Argentina
dc.journal.title
Giornale di Clinica Nefrologica e Dialisi
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.aboutscience.eu/index.php/gcnd/article/view/2490
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.33393/gcnd.2022.2490
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