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dc.contributor.author
Andrade, Bruno G. N.
dc.contributor.author
Cuadrat, Rafael R. C.
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Raya Tonetti, María Fernanda
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Kitazawa, Haruki
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Villena, Julio Cesar
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dc.date.available
2023-07-31T18:10:59Z
dc.date.issued
2022-03
dc.identifier.citation
Andrade, Bruno G. N.; Cuadrat, Rafael R. C.; Raya Tonetti, María Fernanda; Kitazawa, Haruki; Villena, Julio Cesar; The role of respiratory microbiota in the protection against viral diseases: Respiratory commensal bacteria as next-generation probiotics for COVID-19; BMFH Press; Bioscience of Microbiota, Food and Health; 41; 3; 3-2022; 94-102
dc.identifier.issn
2186-6953
dc.identifier.uri
http://hdl.handle.net/11336/206230
dc.description.abstract
On March 11, 2020, the World Health Organization declared a pandemic of coronavirusinfectious disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) and imposed the biggest public health challenge for our civilization, with unforeseenimpacts in the subsequent years. Similar to other respiratory infections, COVID-19 is associated withsignificant changes in the composition of the upper respiratory tract microbiome. Studies have pointed to asignificant reduction of diversity and richness of the respiratory microbiota in COVID-19 patients.Furthermore, it has been suggested that Prevotella, Staphylococcus, and Streptococcus are associated withsevere COVID-19 cases, while Dolosigranulum and Corynebacterium are significantly more abundant inasymptomatic subjects or with mild disease. These results have stimulated the search for newmicroorganisms from the respiratory microbiota with probiotic properties that could alleviate symptomsand even help in the fight against COVID-19. To date, the potential positive effects of probiotics in thecontext of SARS-CoV-2 infection and COVID-19 pandemics have been extrapolated from studies carriedout with other viral pathogens, such as influenza virus and respiratory syncytial virus. However, scientificevidence has started to emerge demonstrating the capacity of immunomodulatory bacteria to beneficiallyinfluence the resistance against SARS-CoV-2 infection. Here we review the scientific knowledge regardingthe role of the respiratory microbiota in viral infections in general and in the infection caused bySARS-CoV-2 in particular. In addition, the scientific work that supports the use of immunomodulatoryprobiotic microorganisms as beneficial tools to reduce the severity of respiratory viral infections is alsoreviewed. In particular, our recent studies that evaluated the role of immunomodulatory Dolosigranulumpigrum strains in the context of SARS-CoV-2 infection are highlighted
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BMFH Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
CORONAVIRUS INFECTIOUS DISEASE 2019 (COVID-19)
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DOLOSIGRANULUM PIGRUM
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PROBIOTICS
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RESPIRATORY MICROBIOTA
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RESPIRATORY VIRAL INFECTIONS
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SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2)
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COVID-19
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
The role of respiratory microbiota in the protection against viral diseases: Respiratory commensal bacteria as next-generation probiotics for COVID-19
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T19:00:32Z
dc.identifier.eissn
2186-3342
dc.journal.volume
41
dc.journal.number
3
dc.journal.pagination
94-102
dc.journal.pais
Japón
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dc.journal.ciudad
Tokyo
dc.conicet.avisoEditorial
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
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Fil: Andrade, Bruno G. N.. Munster Technological University; Irlanda
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Fil: Cuadrat, Rafael R. C.. German Institute of Human Nutrition Potsdam-Rehbrücke. Department of Molecular Epidemiology; Alemania. Max Delbrück Center for Molecular Medicine in the Helmholtz Association. Berlin Institute for Medical Systems Biology; Alemania
dc.description.fil
Fil: Raya Tonetti, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: Kitazawa, Haruki. Tohoku University; Japón
dc.description.fil
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Tohoku University; Japón
dc.journal.title
Bioscience of Microbiota, Food and Health
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.jstage.jst.go.jp/article/bmfh/41/3/41_2022-009/_article
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/ 10.12938/bmfh.2022-009
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