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dc.contributor.author
Maarouf, Chera L.
dc.contributor.author
Andacht, Tracy M.
dc.contributor.author
Kokjohn, Tyler A.
dc.contributor.author
Castaño, Eduardo Miguel
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dc.contributor.author
Sue, Lucia I.
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Beach, Thomas G.
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Roher, Alex E.
dc.date.available
2017-07-14T17:51:21Z
dc.date.issued
2009-08
dc.identifier.citation
Maarouf, Chera L.; Andacht, Tracy M.; Kokjohn, Tyler A.; Castaño, Eduardo Miguel; Sue, Lucia I.; et al.; Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects; Bentham Science Publishers; Current Alzheimer Research; 6; 4; 8-2009; 339-406
dc.identifier.issn
1567-2050
dc.identifier.uri
http://hdl.handle.net/11336/20618
dc.description.abstract
A crucial need exists for reliable Alzheimer's disease (AD) diagnostic and prognostic tests. Given its intimate communication with the brain, the cerebrospinal fluid (CSF) has been surveyed intensively for reliable AD biomarkers. The heterogeneity of AD pathology and the unavoidable difficulties associated with the clinical diagnosis and differentiation of this dementia from other pathologies have confounded biomarker studies in antemortem CSF samples. Using postmortem ventricular CSF (V-CSF) pools, two-dimensional difference gel electrophoresis (2D DIGE) analyses revealed a set of proteins that showed significant differences between neuropathologically-diagnosed AD and elderly non-demented controls (NDC), as well as subjects with non-AD dementias. The 2D DIGE system identified a set of 21 different protein biomarkers. This panel of proteins probably reflects fundamental pathological changes that are divergent from both normal aging and non-AD dementias.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Alzheimer'S Disease
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Cerebrospinal Fluid
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Proteomics
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Biomarkers
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-11T19:28:21Z
dc.identifier.eissn
1875-5828
dc.journal.volume
6
dc.journal.number
4
dc.journal.pagination
339-406
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Maarouf, Chera L.. Sun Health Research Institute; Estados Unidos
dc.description.fil
Fil: Andacht, Tracy M.. University of Georgia; Grecia
dc.description.fil
Fil: Kokjohn, Tyler A.. Sun Health Research Institute; Estados Unidos
dc.description.fil
Fil: Castaño, Eduardo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Sue, Lucia I.. Sun Health Research Institute; Estados Unidos
dc.description.fil
Fil: Beach, Thomas G.. Sun Health Research Institute; Estados Unidos
dc.description.fil
Fil: Roher, Alex E.. Sun Health Research Institute; Estados Unidos
dc.journal.title
Current Alzheimer Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/84772/article
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/156720509788929318
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