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dc.contributor.author
Gallina, Jessica
dc.contributor.author
Zanon, Marco
dc.contributor.author
Mikulan, Ezequiel Pablo
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dc.contributor.author
Pietrelli, Mattia
dc.contributor.author
Gambino, Silvia
dc.contributor.author
Ibáñez, Santiago Agustín
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dc.contributor.author
Bertini, Caterina
dc.date.available
2023-07-31T13:24:02Z
dc.date.issued
2022-12
dc.identifier.citation
Gallina, Jessica; Zanon, Marco; Mikulan, Ezequiel Pablo; Pietrelli, Mattia; Gambino, Silvia; et al.; Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients; Springer Heidelberg; Brain Structure & Function; 227; 9; 12-2022; 2939-2956
dc.identifier.issn
1863-2653
dc.identifier.uri
http://hdl.handle.net/11336/206119
dc.description.abstract
Emerging evidence suggests a role of the posterior cortices in regulating alpha oscillatory activity and organizing low-level processing in non-alpha frequency bands. Therefore, posterior brain lesions, which damage the neural circuits of the visual system, might affect functional connectivity patterns of brain rhythms. To test this hypothesis, eyes-closed resting state EEG signal was acquired from patients with hemianopia with left and right posterior lesions, patients without hemianopia with more anterior lesions and healthy controls. Left-lesioned hemianopics showed reduced intrahemispheric connectivity in the range of upper alpha only in the lesioned hemisphere, whereas right-lesioned hemianopics exhibited reduced intrahemispheric alpha connectivity in both hemispheres. In terms of network topology, these impairments were characterized by reduced local functional segregation, with no associated change in global functional integration. This suggests a crucial role of posterior cortices in promoting functional connectivity in the range of alpha. Right-lesioned hemianopics revealed also additional impairments in the theta range, with increased connectivity in this frequency band, characterized by both increased local segregated activity and decreased global integration. This indicates that lesions to right posterior cortices lead to stronger impairments in alpha connectivity and induce additional alterations in local and global low-level processing, suggesting a specialization of the right hemisphere in generating alpha oscillations and in coordinating complex interplays with lower frequency bands. Importantly, hemianopic patient’s visual performance in the blind field was linked to alpha functional connectivity, corroborating the notion that alpha oscillatory patterns represent a biomarker of the integrity and the functioning of the underlying visual system.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Heidelberg
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ALPHA OSCILLATIONS
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FUNCTIONAL CONNECTIVITY
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HEMIANOPIA
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RESTING STATE
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THETA OSCILLATIONS
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Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-27T14:27:07Z
dc.journal.volume
227
dc.journal.number
9
dc.journal.pagination
2939-2956
dc.journal.pais
Alemania
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dc.description.fil
Fil: Gallina, Jessica. Universidad de Bologna; Italia
dc.description.fil
Fil: Zanon, Marco. Universidad de Bologna; Italia
dc.description.fil
Fil: Mikulan, Ezequiel Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Università degli Studi di Milano; Italia
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Fil: Pietrelli, Mattia. Universidad de Bologna; Italia
dc.description.fil
Fil: Gambino, Silvia. Universidad de Bologna; Italia
dc.description.fil
Fil: Ibáñez, Santiago Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile
dc.description.fil
Fil: Bertini, Caterina. Universidad de Bologna; Italia
dc.journal.title
Brain Structure & Function
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00429-022-02502-0
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