Artículo

Emergence of KPC-31, a KPC-3 Variant Associated with Ceftazidime-Avibactam Resistance, in an Extensively Drug-Resistant ST235 Pseudomonas aeruginosa Clinical Isolate

Faccone, Diego FranciscoIcon ; de Mendieta, Juan Manuel; Albornoz, Ezequiel PabloIcon ; Chavez, Magali; Genero, Fabiana; Echegorry, Mariano; Ceriana, Paola; Mora, Andrea; Seah, Christine; Corso, Alejandra; Melano, Roberto Gustavo; Pasteran, Fernando
Fecha de publicación: 11/2022
Editorial: American Society for Microbiology
Revista: Antimicrobial Agents and Chemotherapy
ISSN: 0066-4804
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

A ceftazidime-avibactam-resistant KPC-producing Pseudomonas aeruginosa strain was isolated in Argentina from a tracheal aspirate. The patient was treated with ceftazidime-avibactam in combination with other agents for 130 days. Whole-genome sequencing of P. aeruginosa identified a D179Y substitution in the X loop of KPC-3, corresponding to KPC-31, integrated at the chromosome. The strain belonged to the sequence type 235/O11 (ST235/O11) high-risk clone. Evaluation of carbapenemase detection assays most used by clinical laboratories failed to identify the isolate as a KPC producer.
Palabras clave: CEFTAZIDIME-AVIBACTAM RESISTANCE , EXTENSIVELY DRUG-RESISTANT ST235 , KPC , PSEUDOMONAS AERUGINOSA
 
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/206031
DOI: http://dx.doi.org/10.1128/aac.00648-22
URL: https://journals.asm.org/doi/10.1128/aac.00648-22
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Citación
Faccone, Diego Francisco; de Mendieta, Juan Manuel; Albornoz, Ezequiel Pablo; Chavez, Magali; Genero, Fabiana; et al.; Emergence of KPC-31, a KPC-3 Variant Associated with Ceftazidime-Avibactam Resistance, in an Extensively Drug-Resistant ST235 Pseudomonas aeruginosa Clinical Isolate; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 66; 11; 11-2022; 1-5
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