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dc.contributor.author
Formica, María Lina  
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Real, Daniel Andres  
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Picchio, Matías Luis  
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Catlin, Elise  
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Donnelly, Ryan F.  
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Paredes, Alejandro J.  
dc.date.available
2023-07-28T13:11:53Z  
dc.date.issued
2022-12  
dc.identifier.citation
Formica, María Lina; Real, Daniel Andres; Picchio, Matías Luis; Catlin, Elise; Donnelly, Ryan F.; et al.; On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles; Elsevier Ltd; Applied Materials Today; 29; 12-2022; 1-23  
dc.identifier.issn
2352-9407  
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http://hdl.handle.net/11336/205931  
dc.description.abstract
The administration of drugs to the central nervous system (CNS) is primarily controlled by the blood-brain barrier (BBB), a structure that prevents the passage of foreign compounds from the blood to the brain´s extracellular fluid. Although currently available treatments for brain diseases that affect millions of people globally are partially effective, they are associated with severe side effects of systemic drug distribution. On the other hand, the ability of certain drugs to permeate through the BBB is impeded by their physicochemical properties, achieving sub-therapeutic concentrations in their target tissues. In this sense, the intranasal route with its unique anatomical features provides a promising passage for the delivery of drugs to the brain. Nanoparticle-based systems, in particular, have demonstrated an outstanding capacity to overcome the challenges presented by the intranasal route and produce drug accumulation in the brain while avoiding systemic distribution. This review covers recent developments in the use of polymer, lipid, and inorganic nanoparticles, as well as drug nanocrystals, to deliver drugs to the brain via intranasal administration. A general discussion including favourable aspects and limitations of this approach is also provided.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Ltd  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
BRAIN TARGETING  
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FUNCTIONAL NANOPARTICLES  
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INTRANASAL ADMINISTRATION  
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NANOCRYSTALS  
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NOSE-TO-BRAIN DELIVERY  
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Nano-materiales  
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Nanotecnología  
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INGENIERÍAS Y TECNOLOGÍAS  
dc.title
On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-07-24T13:55:50Z  
dc.identifier.eissn
2352-9415  
dc.journal.volume
29  
dc.journal.pagination
1-23  
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Países Bajos  
dc.description.fil
Fil: Formica, María Lina. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina  
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Fil: Real, Daniel Andres. Universidad de Chile; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina  
dc.description.fil
Fil: Picchio, Matías Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina  
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Fil: Catlin, Elise. The Queens University of Belfast; Irlanda  
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Fil: Donnelly, Ryan F.. The Queens University of Belfast; Irlanda  
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Fil: Paredes, Alejandro J.. The Queens University of Belfast; Irlanda  
dc.journal.title
Applied Materials Today  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.apmt.2022.101631  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2352940722002657