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dc.contributor.author
Dentice Maidana, Stefania
dc.contributor.author
Ortiz Moyano, Francisco Ramiro
dc.contributor.author
Vargas, Juan Martin
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Fukuyama, Kohtaro
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Kurata, Shoichiro
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Melnikov, Vyacheslav
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Jure, Maria Angela
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Kitazawa, Haruki
dc.contributor.author
Villena, Julio Cesar
dc.date.available
2023-07-27T19:18:42Z
dc.date.issued
2022-09-19
dc.identifier.citation
Dentice Maidana, Stefania; Ortiz Moyano, Francisco Ramiro; Vargas, Juan Martin; Fukuyama, Kohtaro; Kurata, Shoichiro; et al.; Respiratory Commensal Bacteria Increase Protection against Hypermucoviscous Carbapenem-Resistant Klebsiella pneumoniae ST25 Infection; Multidisciplinary Digital Publishing Institute; Pathogens; 11; 9; 19-9-2022; 1-11
dc.identifier.issn
2076-0817
dc.identifier.uri
http://hdl.handle.net/11336/205858
dc.description.abstract
In a previous work, we demonstrated that nasally administered Corynebacterium pseudodiphtheriticum 090104 beneficially modulated the respiratory innate immune response and improved the protection against Respiratory Syncytial Virus and Streptococcus pneumoniae in mice. In this work, we aimed to evaluate whether the immunomodulatory 090104 strain was able to enhance the resistance against the respiratory infection induced by hypermucoviscous carbapenemase-producing (KPC-2) Klebsiella pneumoniae strains belonging to the sequence type (ST) 25. The nasal treatment of mice with C. pseudodiphtheriticum 090104 before the challenge with multiresistant K. pneumoniae ST25 strains significantly reduced lung bacterial cell counts and lung tissue damage. The protective effect of the 090104 strain was related to its ability to regulate the respiratory innate immune response triggered by K. pneumoniae challenge. C. pseudifteriticum 090104 differentially modulated the recruitment of leukocytes into the lung and the production of TNF-α, IFN-γ and IL-10 levels in the respiratory tract and serum. Our results make an advance in the positioning of C. pseudodiphtheriticum 090104 as a next-generation probiotic for the respiratory tract and encourage further research of this bacterium as a promising alternative to develop non-antibiotic therapeutical approaches to enhance the prevention of infections produced by microorganisms with multiple resistance to antimicrobials such as KPC-2-producing hypermucoviscous K. pneumoniae strains belonging to ST25.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Multidisciplinary Digital Publishing Institute
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ANTIBIOTIC RESISTANCE
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CORYNEBACTERIUM PSEUDODIPHTHERITICUM
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IMMUNOBIOTIC
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KLEBSIELLA PNEUMONIAE
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NEXT GENERATION PROBIOTICS
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RESPIRATORY COMMENSAL BACTERIA
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RESPIRATORY IMMUNITY
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Respiratory Commensal Bacteria Increase Protection against Hypermucoviscous Carbapenem-Resistant Klebsiella pneumoniae ST25 Infection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T19:00:49Z
dc.journal.volume
11
dc.journal.number
9
dc.journal.pagination
1-11
dc.journal.pais
Suiza
dc.description.fil
Fil: Dentice Maidana, Stefania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología; Argentina
dc.description.fil
Fil: Ortiz Moyano, Francisco Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: Vargas, Juan Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología; Argentina
dc.description.fil
Fil: Fukuyama, Kohtaro. Tohoku University; Japón
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Fil: Kurata, Shoichiro. Tohoku University; Japón
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Fil: Melnikov, Vyacheslav. Gabrichevsky Research Institute for Epidemiology and Microbiology; Rusia
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Fil: Jure, Maria Angela. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología; Argentina
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Fil: Kitazawa, Haruki. Tohoku University; Japón
dc.description.fil
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Tohoku University; Japón
dc.journal.title
Pathogens
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-0817/11/9/1063
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/pathogens11091063
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