Artículo
Disentangling Signatures of Selection before and after European Colonization in Latin Americans
Mendoza Revilla, Javier; Chacón Duque, J. Camilo; Fuentes Guajardo, Macarena; Ormond, Louise; Wang, Ke; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Acuña Alonzo, Victor; Jaramillo, Claudia; Arias, William; Barquera, Rodrigo; Gómez ValdCrossed D Sign©s, Jorge; Villamil Ramírez, Hugo; Silva De Cerqueira, Caio C.; Badillo Rivera, Keyla M.; Nieves Colón, Maria A.; Gignoux, Christopher R.; Wojcik, Genevieve L.; Moreno Estrada, Andrés; Hünemeier, Tábita; Ramallo, Virginia
; Schuler Faccini, Lavinia; Gonzalez-Jose, Rolando
; Bortolini, Maria Cátira; Canizales Quinteros, Samuel; Gallo, Carla; Poletti, Giovanni; Bedoya, Gabriel; Rothhammer, Francisco; Balding, David; Fumagalli, Matteo; Adhikari, Kaustubh; Ruiz Linares, Andrés; Hellenthal, Garrett
Fecha de publicación:
04/2022
Editorial:
Oxford University Press
Revista:
Molecular Biology and Evolution
ISSN:
0737-4038
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Throughout human evolutionary history, large-scale migrations have led to intermixing (i.e., admixture) between previously separated human groups. Although classical and recent work have shown that studying admixture can yield novel historical insights, the extent to which this process contributed to adaptation remains underexplored. Here, we introduce a novel statistical model, specific to admixed populations, that identifies loci under selection while determining whether the selection likely occurred post-admixture or prior to admixture in one of the ancestral source populations. Through extensive simulations, we show that this method is able to detect selection, even in recently formed admixed populations, and to accurately differentiate between selection occurring in the ancestral or admixed population. We apply this method to genome-wide SNP data of ∼4,000 individuals in five admixed Latin American cohorts from Brazil, Chile, Colombia, Mexico, and Peru. Our approach replicates previous reports of selection in the human leukocyte antigen region that are consistent with selection post-admixture. We also report novel signals of selection in genomic regions spanning 47 genes, reinforcing many of these signals with an alternative, commonly used local-ancestry-inference approach. These signals include several genes involved in immunity, which may reflect responses to endemic pathogens of the Americas and to the challenge of infectious disease brought by European contact. In addition, some of the strongest signals inferred to be under selection in the Native American ancestral groups of modern Latin Americans overlap with genes implicated in energy metabolism phenotypes, plausibly reflecting adaptations to novel dietary sources available in the Americas.
Palabras clave:
ADMIXTURE
,
LATIN AMERICANS
,
NATIVE AMERICANS
,
NATURAL SELECTION
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IPCSH)
Articulos de INSTITUTO PATAGONICO DE CIENCIAS SOCIALES Y HUMANAS
Articulos de INSTITUTO PATAGONICO DE CIENCIAS SOCIALES Y HUMANAS
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Mendoza Revilla, Javier; Chacón Duque, J. Camilo; Fuentes Guajardo, Macarena; Ormond, Louise; Wang, Ke; et al.; Disentangling Signatures of Selection before and after European Colonization in Latin Americans; Oxford University Press; Molecular Biology and Evolution; 39; 4; 4-2022; 1-26
Compartir
Altmétricas