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dc.contributor.author
Pérez Zamora, Cristina Marisel
dc.contributor.author
Michaluk, Ariel German
dc.contributor.author
Chiappetta, Diego Andrés
dc.contributor.author
Nuñez, María Beatriz
dc.date.available
2023-07-26T15:59:27Z
dc.date.issued
2022-02
dc.identifier.citation
Pérez Zamora, Cristina Marisel; Michaluk, Ariel German; Chiappetta, Diego Andrés; Nuñez, María Beatriz; Herbal buccal films with in vitro antibacterial and anti-inflammatory effects; Elsevier; Journal of Herbal Medicine; 31; 2-2022; 1-13
dc.identifier.issn
2210-8033
dc.identifier.uri
http://hdl.handle.net/11336/205628
dc.description.abstract
In recent years, natural products have been studied as antimicrobial agents and as compounds to develop phytomedicines. Although they are also useful to treat buccal infections, the oral cavity has characteristics that impair the development of topical buccal pharmaceuticals. Thus, the aim of this work was to develop buccal films, including a combination of Lippia turbinata and Lippia alba extracts, with anti-inflammatory and antibacterial activity, pleasant organoleptic characteristics, mucoadhesive capacity, good mechanical properties and ability to not quickly dissolve in the oral cavity. Firstly, the extracts were characterized by their phenolic profile (HPLC-PDA-ESI-MS/MS), and antibacterial (broth microdilution and checkerboard assays) and anti-inflammatory (in vitro LOX inhibitory activity) activities. The films were produced using the solvent casting method. The film-forming polymers were hydroxypropylmethylcellulose alone and hydroxypropylmethylcellulose combined with Eudragit® polymers. The films were characterized by their physico-chemical properties, color, mucoadhesiveness, mechanical properties, release profile, and permeation performance. The main polyphenolic components found in the extracts were flavones. The combination of extracts improved the antibacterial and anti-inflammatory activities. All films presented acceptable organoleptic characteristics. The chromatic values were those expected for plant extracts and the appearance of superface varied according to the polymers used. The inclusion of Eudragit® in the formulations modified their microstructure, giving them elasticity, increasing their swelling index and release rate, and accelerating the permeation of polyphenols in the porcine oral mucosa. The characteristics of the films evaluated were acceptable for use. In addition, the P3 film presented better mucoadhesion, which makes it more appropriate for oral application.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HERBAL FILM
dc.subject
LIPPIA ALBA
dc.subject
LIPPIA TURBINATA
dc.subject
MUCOADHESIVE FILM
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PHARMACEUTICAL DEVELOPMENT
dc.subject
TOPICAL TREATMENT
dc.subject.classification
Otras Ciencias Naturales y Exactas
dc.subject.classification
Otras Ciencias Naturales y Exactas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Herbal buccal films with in vitro antibacterial and anti-inflammatory effects
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-13T14:30:21Z
dc.identifier.eissn
2210-8041
dc.journal.volume
31
dc.journal.pagination
1-13
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Pérez Zamora, Cristina Marisel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Nordeste. Instituto de Investigaciones En Procesos Tecnologicos Avanzados. - Universidad Nacional del Chaco Austral. Instituto de Investigaciones En Procesos Tecnologicos Avanzados.; Argentina
dc.description.fil
Fil: Michaluk, Ariel German. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Nordeste. Instituto de Investigaciones En Procesos Tecnologicos Avanzados. - Universidad Nacional del Chaco Austral. Instituto de Investigaciones En Procesos Tecnologicos Avanzados.; Argentina
dc.description.fil
Fil: Chiappetta, Diego Andrés. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Nuñez, María Beatriz. Universidad Nacional del Chaco Austral; Argentina
dc.journal.title
Journal of Herbal Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S221080332100107X
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.hermed.2021.100527
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