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dc.contributor.author
del Carmen, Silvina Andrea
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dc.contributor.author
Martin Rosique, Rebeca
dc.contributor.author
Saraiva, Tessália
dc.contributor.author
Zurita Turk, Meritxell
dc.contributor.author
Miyoshi, Anderson
dc.contributor.author
Azevedo, Vasco
dc.contributor.author
de Moreno, Maria Alejandra
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dc.contributor.author
Langella, Philippe
dc.contributor.author
Bermudez-Humaran, Luis G.
dc.contributor.author
Leblanc, Jean Guy Joseph
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dc.date.available
2017-07-14T16:52:12Z
dc.date.issued
2014-11
dc.identifier.citation
del Carmen, Silvina Andrea; Martin Rosique, Rebeca; Saraiva, Tessália; Zurita Turk, Meritxell; Miyoshi, Anderson; et al.; Protective effects of lactococci strains delivering either IL-10 protein or cDNA in a TNBS-induced chronic colitis model; Williams & Wilkins; Journal Of Clinical Gastroenterology; 48; S1; 11-2014; S12-17
dc.identifier.issn
0192-0790
dc.identifier.uri
http://hdl.handle.net/11336/20553
dc.description.abstract
Background: Oral treatment with Lactococcus (L.) lactis strains secreting the anti-inflammatory cytokine IL-10 has previously shown success as a therapy for inflammatory bowel diseases (IBD). Goals: Our aim was to compare the protective effects of IL-10, delivered by recombinant lactoccoci using two novel expression systems, in a murine colitis model mimicking the relapsing nature of IBD. The first system is based on a Stress-Inducible Controlled Expression (SICE) system for the production and delivery of heterologous proteins at mucosal surfaces and the second allows the delivery to the host cells of an il-10 cDNA cassette, harbored in a eukaryotic DNA expression vector (pValac). Study: Colitis was induced in female BALB/c mice by intrarectal injection of 2,4,6-trinitrobenzenesulphonic acid (TNBS). Mice that recovered received one of the bacteria treatments or saline solution orally during 14 days. Colitis was reactivated 25 days after the first TNBS injection with a second TNBS challenge. Three days after colitis reactivation, cytokine profiles and inflammation in colon samples were evaluated. Results: Animals (N=9) receiving L. lactis strains secreting IL-10 using SICE system or delivering pValac:il-10 plasmid showed lower weight loss (p<0.005), lower damage scores (p<0.005) and immune activation in their large intestines compared to inflamed non-treated mice. Conclusions: Our results confirm the protective effect of IL-10 delivered either as a protein or as a cDNA in a colitis model mimicking the relapsing nature of IBD and provides a step further in the ?proof-of-concept? of genetically engineered bacteria as a valid system to deliver therapeutic molecules at mucosal level.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Williams & Wilkins
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Lactococcus Lactis
dc.subject
Interleukin-10
dc.subject
Dna Vaccine
dc.subject
Inflammatory Bowel Diseases (Ibd)
dc.subject.classification
Otras Ingenierías y Tecnologías
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dc.subject.classification
Otras Ingenierías y Tecnologías
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Protective effects of lactococci strains delivering either IL-10 protein or cDNA in a TNBS-induced chronic colitis model
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-03T20:14:25Z
dc.identifier.eissn
1539-2031
dc.journal.volume
48
dc.journal.number
S1
dc.journal.pagination
S12-17
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: del Carmen, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil
Fil: Martin Rosique, Rebeca. Institut National de la Recherche Agronomique; Francia
dc.description.fil
Fil: Saraiva, Tessália. Universidade Federal do Minas Gerais; Brasil
dc.description.fil
Fil: Zurita Turk, Meritxell. Universidade Federal do Minas Gerais; Brasil
dc.description.fil
Fil: Miyoshi, Anderson. Universidade Federal do Minas Gerais; Brasil
dc.description.fil
Fil: Azevedo, Vasco. Universidade Federal do Minas Gerais; Brasil
dc.description.fil
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil
Fil: Langella, Philippe. Institut National de la Recherche Agronomique; Francia
dc.description.fil
Fil: Bermudez-Humaran, Luis G.. Institut National de la Recherche Agronomique; Francia
dc.description.fil
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.journal.title
Journal Of Clinical Gastroenterology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1097/MCG.0000000000000235
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/jcge/pages/articleviewer.aspx?year=2014&issue=11001&article=00007&type=abstract
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