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dc.contributor.author
García Mendez, David
dc.contributor.author
Rengifo Herrera, Julian Andres
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dc.contributor.author
Sanabria, Janeth
dc.contributor.author
Wist, Julien
dc.date.available
2023-07-25T12:22:44Z
dc.date.issued
2022-06-30
dc.identifier.citation
García Mendez, David; Rengifo Herrera, Julian Andres; Sanabria, Janeth; Wist, Julien; Analysis of the metabolic response of planktonic cells and biofilms of klebsiella pneumoniae to sublethal disinfection with sodium hypochlorite measured by NMR; MDPI; Microorganisms; 10; 7; 30-6-2022; 1-11
dc.identifier.issn
2076-2607
dc.identifier.uri
http://hdl.handle.net/11336/205202
dc.description.abstract
Klebsiella pneumoniae is a pathogenic agent able to form biofilms on water storage tanks and pipe walls. This opportunistic pathogen can generate a thick layer as one of its essential virulence factors, enabling the bacteria to survive disinfection processes and thus develop drug resistance. Understanding the metabolic differences between biofilm and planktonic cells of the K. pneumoniae response to NaClO is key to developing strategies to control its spread. In this study, we performed an NMR metabolic profile analysis to compare the response to a sublethal concentration of sodium hypochlorite of biofilm and planktonic cells of K. pneumoniae cultured inside silicone tubing. Metabolic profiles revealed changes in the metabolism of planktonic cells after a contact time of 10 min with 7 mg L1 of sodium hypochlorite. A decrease in the production of metabolites such as lactate, acetate, ethanol, and succinate in this cell type was observed, thus indicating a disruption of glucose intake. In contrast, the biofilms displayed a high metabolic heterogeneity, and the treatment did not affect their metabolic signature.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
CHLORINATION
dc.subject
CHLORINE
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EXOMETABOLOME
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KLEBSIELLA
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METABOLISM
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METABOLITE
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NAOCL
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WATER
dc.subject.classification
Otras Ciencias Químicas
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Analysis of the metabolic response of planktonic cells and biofilms of klebsiella pneumoniae to sublethal disinfection with sodium hypochlorite measured by NMR
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T18:40:51Z
dc.journal.volume
10
dc.journal.number
7
dc.journal.pagination
1-11
dc.journal.pais
Suiza
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dc.journal.ciudad
Basel
dc.description.fil
Fil: García Mendez, David. Universidad del Valle; Colombia
dc.description.fil
Fil: Rengifo Herrera, Julian Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas "Dr. Jorge J. Ronco". Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Ciencias Aplicadas; Argentina
dc.description.fil
Fil: Sanabria, Janeth. Universidad del Valle; Colombia
dc.description.fil
Fil: Wist, Julien. Universidad del Valle; Colombia
dc.journal.title
Microorganisms
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-2607/10/7/1323
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.3390/microorganisms10071323
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