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dc.contributor.author
Adam, Alexandre
dc.contributor.author
Harlepp, Sébastien
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Ghilini, Fiorela
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dc.contributor.author
Cotin, Geoffrey
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Freis, Barbara
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Goetz, Jacky
dc.contributor.author
Bégin, Sylvie
dc.contributor.author
Tasso, Mariana Patricia
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dc.contributor.author
Mertz, Damien
dc.date.available
2023-07-25T11:45:29Z
dc.date.issued
2022-05
dc.identifier.citation
Adam, Alexandre; Harlepp, Sébastien; Ghilini, Fiorela; Cotin, Geoffrey; Freis, Barbara; et al.; Core-shell iron oxide@stellate mesoporous silica for combined near-infrared photothermia and drug delivery: Influence of pH and surface chemistry; Elsevier Science; Colloids and Surfaces A: Physicochemical and Engineering Aspects; 640; 128407; 5-2022; 1-12
dc.identifier.issn
0927-7757
dc.identifier.uri
http://hdl.handle.net/11336/205173
dc.description.abstract
The chemical design of smart nanocarriers, providing in one nanoformulation combined anticancer therapies, still remains a challenge in the field of nanomedicine. Among nanomaterials, iron oxide-based core-shell nanostructures have been already studied for their intrinsic magnetic hyperthermia features that may be coupled with drug delivery. However, despite the great interest today for photo-induced hyperthermia, very few studies investigated the potential of such nanocarriers to combine photothermia and drug delivery. In this work, our aim was to design functional iron oxide@stellate mesoporous silica nanoparticles (denoted IO@STMS NPs) loaded with a drug and able to combine in a same formulation near-infrared (NIR) light induced photothermia with antitumor drug release. Herein, the NIR photothermal properties (SAR, specific absorption rates) of such nanomaterials were quantified for the first time as a function of the laser power and the NP amount. Aside the response to NIR light, the conditions to obtain very high drug loading (drug payloads up to 91 wt%) of the model antitumor drug doxorubicin (DOX) were optimized by varying different parameters, such as the NP surface chemistry (BARE (Si-OH), aminopropylsiloxane (APTES) and isobutyramide (IBAM)) and the pH of the drug impregnation aqueous solution. The drug release study of these core-shell systems in the presence or absence of NIR light demonstrated that the DOX release efficiency is mainly influenced by two parameters: surface chemistry (BARE ≥ IBAM ≥ APTES) and pH (pH 5.5 ≥ pH 6.5 ≥ pH 7.5). Furthermore, the temperature profiles under NIR light are found similar and independent from the pH range, the surface chemistry and the cycle number. Hence, the combination of local photothermia with lysosomal-like pH induced drug delivery (up to 40% release of the loaded drug) with these nanostructures could open the way towards new drug delivery nanoplatforms for nanomedecine applications.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
DRUG DELIVERY
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IRON OXIDE@MESOPOROUS SILICA
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NEAR-INFRARED PHOTO-INDUCED HYPERTHERMIA
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SURFACE CHEMISTRY
dc.subject.classification
Otras Ciencias Químicas
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Core-shell iron oxide@stellate mesoporous silica for combined near-infrared photothermia and drug delivery: Influence of pH and surface chemistry
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-05T12:12:36Z
dc.journal.volume
640
dc.journal.number
128407
dc.journal.pagination
1-12
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Adam, Alexandre. Universite de Strasbourg. Unite de Recherche.; Francia
dc.description.fil
Fil: Harlepp, Sébastien. Université de Strasbourg; Francia
dc.description.fil
Fil: Ghilini, Fiorela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
dc.description.fil
Fil: Cotin, Geoffrey. Université de Strasbourg; Francia
dc.description.fil
Fil: Freis, Barbara. Université de Strasbourg; Francia
dc.description.fil
Fil: Goetz, Jacky. Université de Strasbourg; Francia. Inserm; Francia
dc.description.fil
Fil: Bégin, Sylvie. Université de Strasbourg; Francia
dc.description.fil
Fil: Tasso, Mariana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
dc.description.fil
Fil: Mertz, Damien. Université de Strasbourg; Francia
dc.journal.title
Colloids and Surfaces A: Physicochemical and Engineering Aspects
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0927775722001613
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.colsurfa.2022.128407
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