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dc.contributor.author
Baier, Carlos Javier
dc.contributor.author
Barrantes, Francisco Jose
dc.date.available
2023-07-25T01:39:21Z
dc.date.issued
2023-02
dc.identifier.citation
Baier, Carlos Javier; Barrantes, Francisco Jose; Role of cholesterol-recognition motifs in the infectivity of SARS-CoV-2 variants; Elsevier Science; Colloids and Surfaces B: Biointerfaces; 222; 113090; 2-2023; 1-6
dc.identifier.issn
0927-7765
dc.identifier.uri
http://hdl.handle.net/11336/205124
dc.description.abstract
The presence of linear amino acid motifs with the capacity to recognize the neutral lipid cholesterol, known as Cholesterol Recognition/interaction Amino acid Consensus sequence (CRAC), and its inverse or mirror image, CARC, has recently been reported in the primary sequence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike S homotrimeric glycoprotein. These motifs also occur in the two other pathogenic coronaviruses, SARS-CoV, and Middle-East respiratory syndrome CoV (MERS-CoV), most conspicuously in the transmembrane domain, the fusion peptide, the amino-terminal domain, and the receptor binding domain of SARS-CoV-2 S protein. Here we analyze the presence of cholesterol-recognition motifs in these key regions of the spike glycoprotein in the pathogenic CoVs. We disclose the inherent pathophysiological implications of the cholesterol motifs in the virus-host cell interactions and variant infectivity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CELL-SURFACE PHENOMENA
dc.subject
CHOLESTEROL
dc.subject
CHOLESTEROL RECOGNITION MOTIFS
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CHOLESTEROL-PROTEIN INTERACTIONS
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FUSION PROTEINS
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VIRAL INFECTIVITY
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Role of cholesterol-recognition motifs in the infectivity of SARS-CoV-2 variants
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T18:23:20Z
dc.identifier.eissn
1873-4367
dc.journal.volume
222
dc.journal.number
113090
dc.journal.pagination
1-6
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Baier, Carlos Javier. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Toxicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
dc.description.fil
Fil: Barrantes, Francisco Jose. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Colloids and Surfaces B: Biointerfaces
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0927776522007743
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.colsurfb.2022.113090
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