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dc.contributor.author
Fustero, Santos
dc.contributor.author
Roman, Raquel
dc.contributor.author
Sanz Cervera, Juan F.
dc.contributor.author
Simon Fuentes, Antonio
dc.contributor.author
Cuñat, Ana
dc.contributor.author
Villanova, Salvador
dc.contributor.author
Murguia, Marcelo Cesar
dc.date.available
2017-07-14T14:19:13Z
dc.date.issued
2008-12
dc.identifier.citation
Fustero, Santos; Roman, Raquel; Sanz Cervera, Juan F.; Simon Fuentes, Antonio; Cuñat, Ana; et al.; Improved Regioselectivity in Pyrazole Formation through the Use of Fluorinated Alcohols as Solvents: Synthesis and Biological Activity of Fluorinated Tebufenpyrad Analogs; American Chemical Society; Journal of Organic Chemistry; 73; 9; 12-2008; 3523-3529
dc.identifier.issn
0022-3263
dc.identifier.uri
http://hdl.handle.net/11336/20497
dc.description.abstract
The preparation of N-methylpyrazoles is usually accomplished through reaction of a suitable 1,3-diketone with methylhydrazine in ethanol as the solvent. This strategy, however, leads to the formation of regioisomeric mixtures of N-methylpyrazoles, which sometimes are difficult to separate. We have determined that the use of fluorinated alcohols such as 2,2,2-trifluoroethanol (TFE) and 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as solvents dramatically increases the regioselectivity in the pyrazole formation, and we have used this modification in a straightforward synthesis of fluorinated analogs of Tebufenpyrad with acaricide activity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Pyrazol
dc.subject
Fluorinated Pyrazol
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Fluorous
dc.subject
Tebufenpyrad
dc.subject.classification
Química Orgánica
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Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Improved Regioselectivity in Pyrazole Formation through the Use of Fluorinated Alcohols as Solvents: Synthesis and Biological Activity of Fluorinated Tebufenpyrad Analogs
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-10T13:10:11Z
dc.journal.volume
73
dc.journal.number
9
dc.journal.pagination
3523-3529
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Fustero, Santos. Universidad de Valencia; España
dc.description.fil
Fil: Roman, Raquel. Universidad de Valencia; España
dc.description.fil
Fil: Sanz Cervera, Juan F.. Universidad de Valencia; España. Centro de Investigaciones Principe Felipe; España
dc.description.fil
Fil: Simon Fuentes, Antonio. Universidad de Valencia; España
dc.description.fil
Fil: Cuñat, Ana. Universidad de Valencia; España
dc.description.fil
Fil: Villanova, Salvador. Universidad de Valencia; España
dc.description.fil
Fil: Murguia, Marcelo Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.journal.title
Journal of Organic Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/jo800251g
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/jo800251g


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