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dc.contributor.author Tamiozzo, S.R.
dc.contributor.author Lassen, O.C.
dc.contributor.author Herrera, Jimena María
dc.contributor.author Igarzabal, P.
dc.contributor.author Tabares, S.
dc.contributor.author Sembaj, Adela
dc.date.available 2017-07-13T21:29:14Z
dc.date.issued 2017-06
dc.identifier.citation Tamiozzo, S.R.; Lassen, O.C.; Herrera, Jimena María; Igarzabal, P.; Tabares, S.; et al.; Polimorfismos de un solo nucleótido en genes de endotelina-1 y su receptor A asociados a daño cardiovascular en hipertensión arterial esencial; Elseiver; Hipertensión y Riesgo Vascular; 34; 2; 6-2017; 78-84
dc.identifier.issn 1889-1837
dc.identifier.uri http://hdl.handle.net/11336/20462
dc.description.abstract The endothelin system, for its vasoconstrictor action, is related to the developmentof essential hypertension (HTAe). The polymorphism analysis of their genes representsa new approach to the study of this disease. We propose to analyze the interaction betweenstages of essential hypertension (HTAe) and risk factors with polymorphisms 138ex1 ins/del Agene endothelin-1 (ET-1) and H323H receptor gene A ET-1 (ETRA).Patients and methods: We included 300 patients of both sexes, unrelated, who consecutivelyattended the clinic hypertension medical service. Each one underwent a complete physicalexamination, electrocardiogram, echocardiogram, and Rx thorax. The degree of severity ofhypertension was determined in stages. The determination of polymorphisms was performedby amplification followed by cutting by specific restriction enzyme from DNA obtained fromperipheral blood.Results: The 46% of patients had HTAe controlled, 17.6% had organ damage or cardiovascular,brain or kidney disease. It was observed that the 4A/4A carriers showed lower frequency ofcardiovascular disease, kidney and brain (P<.032; 95% CI: 11.1-21.4). For H323H polymorphism,the evaluation by images showed a higher frequency of the dilations of left auricular (P=.02)and auricular fibrillation (P=.03) between the T/T carrier, a higher frequency of cardiomegalywas detected in C/C patients (P=.04).Conclusion: The genotypes, 4A/4A of the ET-1 gene and the T/T from ETRA gene might beinvolved in worse outcome of cardiovascular damage. Their identification could help recognizesubgroups of the hypertensive patients with different risk
dc.format application/pdf
dc.language.iso spa
dc.publisher Elseiver
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject ESSENTIAL HYPERTENSION
dc.subject ENDOTHELIN-1
dc.subject RECEPTOR A OF ENDOTHELIN-1
dc.subject GENETICS POLYMORPHISMS
dc.subject.classification Sistemas Cardíaco y Cardiovascular
dc.subject.classification Medicina Clínica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Polimorfismos de un solo nucleótido en genes de endotelina-1 y su receptor A asociados a daño cardiovascular en hipertensión arterial esencial
dc.title Single nucleotide polymorphisms in genes of endothelin-1 and receptor A associated to cardiovascular in essential hypertension
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-07-07T20:06:35Z
dc.journal.volume 34
dc.journal.number 2
dc.journal.pagination 78-84
dc.journal.pais España
dc.description.fil Fil: Tamiozzo, S.R.. Universidad Nacional de Córdoba. Facultad de Medicina. Hospital Córdoba; Argentina
dc.description.fil Fil: Lassen, O.C.. Universidad Nacional de Córdoba. Facultad de Medicina. Hospital Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Semiología I; Argentina
dc.description.fil Fil: Herrera, Jimena María. Universidad Nacional de Córdoba. Facultad de Medicina. Cátedra de Bioquímica y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
dc.description.fil Fil: Igarzabal, P.. Universidad Nacional de Córdoba. Facultad de Medicina. Hospital Córdoba; Argentina
dc.description.fil Fil: Tabares, S.. Universidad Nacional de Córdoba. Facultad de Medicina. Cátedra de Bioquímica y Biología Molecular; Argentina
dc.description.fil Fil: Sembaj, Adela. Universidad Nacional de Córdoba. Facultad de Medicina. Cátedra de Bioquímica y Biología Molecular; Argentina
dc.journal.title Hipertensión y Riesgo Vascular
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S188918371630054X
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.hipert.2016.10.003


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)