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dc.contributor.author
Tamiozzo, S.R.
dc.contributor.author
Lassen, O.C.
dc.contributor.author
Herrera, Jimena María
dc.contributor.author
Igarzabal, P.
dc.contributor.author
Tabares, S.
dc.contributor.author
Sembaj, Adela
dc.date.available
2017-07-13T21:29:14Z
dc.date.issued
2017-06
dc.identifier.citation
Tamiozzo, S.R.; Lassen, O.C.; Herrera, Jimena María; Igarzabal, P.; Tabares, S.; et al.; Polimorfismos de un solo nucleótido en genes de endotelina-1 y su receptor A asociados a daño cardiovascular en hipertensión arterial esencial; Elseiver; Hipertensión y Riesgo Vascular; 34; 2; 6-2017; 78-84
dc.identifier.issn
1889-1837
dc.identifier.uri
http://hdl.handle.net/11336/20462
dc.description.abstract
The endothelin system, for its vasoconstrictor action, is related to the developmentof essential hypertension (HTAe). The polymorphism analysis of their genes representsa new approach to the study of this disease. We propose to analyze the interaction betweenstages of essential hypertension (HTAe) and risk factors with polymorphisms 138ex1 ins/del Agene endothelin-1 (ET-1) and H323H receptor gene A ET-1 (ETRA).Patients and methods: We included 300 patients of both sexes, unrelated, who consecutivelyattended the clinic hypertension medical service. Each one underwent a complete physicalexamination, electrocardiogram, echocardiogram, and Rx thorax. The degree of severity ofhypertension was determined in stages. The determination of polymorphisms was performedby amplification followed by cutting by specific restriction enzyme from DNA obtained fromperipheral blood.Results: The 46% of patients had HTAe controlled, 17.6% had organ damage or cardiovascular,brain or kidney disease. It was observed that the 4A/4A carriers showed lower frequency ofcardiovascular disease, kidney and brain (P<.032; 95% CI: 11.1-21.4). For H323H polymorphism,the evaluation by images showed a higher frequency of the dilations of left auricular (P=.02)and auricular fibrillation (P=.03) between the T/T carrier, a higher frequency of cardiomegalywas detected in C/C patients (P=.04).Conclusion: The genotypes, 4A/4A of the ET-1 gene and the T/T from ETRA gene might beinvolved in worse outcome of cardiovascular damage. Their identification could help recognizesubgroups of the hypertensive patients with different risk
dc.format
application/pdf
dc.language.iso
spa
dc.publisher
Elseiver
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Essential Hypertension
dc.subject
Endothelin-1
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Receptor A of Endothelin-1
dc.subject
Genetics Polymorphisms
dc.subject.classification
Sistemas Cardíaco y Cardiovascular
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Polimorfismos de un solo nucleótido en genes de endotelina-1 y su receptor A asociados a daño cardiovascular en hipertensión arterial esencial
dc.title
Single nucleotide polymorphisms in genes of endothelin-1 and receptor A associated to cardiovascular in essential hypertension
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-07T20:06:35Z
dc.journal.volume
34
dc.journal.number
2
dc.journal.pagination
78-84
dc.journal.pais
España
dc.description.fil
Fil: Tamiozzo, S.R.. Universidad Nacional de Córdoba. Facultad de Medicina. Hospital Córdoba; Argentina
dc.description.fil
Fil: Lassen, O.C.. Universidad Nacional de Córdoba. Facultad de Medicina. Hospital Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Semiología I; Argentina
dc.description.fil
Fil: Herrera, Jimena María. Universidad Nacional de Córdoba. Facultad de Medicina. Cátedra de Bioquímica y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
dc.description.fil
Fil: Igarzabal, P.. Universidad Nacional de Córdoba. Facultad de Medicina. Hospital Córdoba; Argentina
dc.description.fil
Fil: Tabares, S.. Universidad Nacional de Córdoba. Facultad de Medicina. Cátedra de Bioquímica y Biología Molecular; Argentina
dc.description.fil
Fil: Sembaj, Adela. Universidad Nacional de Córdoba. Facultad de Medicina. Cátedra de Bioquímica y Biología Molecular; Argentina
dc.journal.title
Hipertensión y Riesgo Vascular
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S188918371630054X
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.hipert.2016.10.003


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