Artículo

Highly sensitive acetylcholine biosensing via chemical amplification of enzymatic processes in nanochannels

Toum Terrones, YamiliIcon ; Laucirica, GregorioIcon ; Cayón, Vanina MabelIcon ; Fenoy, Gonzalo EduardoIcon ; Cortez, María LorenaIcon ; Toimil Molares, María Eugenia; Trautmann, Christina; Mamisollé, Waldemar A.; Azzaroni, OmarIcon
Fecha de publicación: 08/2022
Editorial: Royal Society of Chemistry
Revista: Chemical Communications
ISSN: 1359-7345
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Acetylcholinesterase-modified nanochannels are proposed as reliable and reproducible nanofluidic sensors for highly sensitive detection of acetylcholine. The operation mechanism relies on the use of weak polyelectrolytes as “chemical amplifiers” that adjust/reconfigure the nanochannel surface charge in the presence of local pH changes induced by the enzymatic reaction. Experimental results show that the presence of acetylcholine can be transduced into measurable ionic signals with a low limit of detection.
Palabras clave: acetylcholine biosensing , nanofluidic sensing , nanochannels , biosensing
 
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/204524
DOI: https://doi.org/10.1039/D2CC02249D
URL: https://pubs.rsc.org/en/content/articlelanding/2022/CC/D2CC02249D
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Articulos de INST.DE INV.FISICOQUIMICAS TEORICAS Y APLIC.
Citación
Toum Terrones, Yamili; Laucirica, Gregorio; Cayón, Vanina Mabel; Fenoy, Gonzalo Eduardo; Cortez, María Lorena; et al.; Highly sensitive acetylcholine biosensing via chemical amplification of enzymatic processes in nanochannels; Royal Society of Chemistry; Chemical Communications; 58; 73; 8-2022; 10166-10169
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