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dc.contributor.author
Piloni, Natacha Estefanía  
dc.contributor.author
Puntarulo, Susana Ángela  
dc.contributor.other
Ravi Kumar Chittoria  
dc.date.available
2023-07-19T13:20:22Z  
dc.date.issued
2022  
dc.identifier.citation
Piloni, Natacha Estefanía; Puntarulo, Susana Ángela; Fe overload an ascorbyl radical steady state concentration in rat brain; BP International; 4; 2022; 1-7  
dc.identifier.isbn
978-93-5547-456-8  
dc.identifier.uri
http://hdl.handle.net/11336/204439  
dc.description.abstract
The one-electron oxidation of ascorbate produces the ascorbyl radical (A●), that has been proposed as a marker of oxidative stress either in vitro, or in vivo in numerous systems. The application of a simple kinetic analysis allowed us to estimate the steady state concentration of A●. These data were successfully compared to experimental values obtained in rat brain under physiological conditions and in response to stress due to sub-chronic Fe overload. The main objective of this chapter is to further explore the information presented in a previously published manuscript employing a simple kinetic model developed to estimate A● state concentration to other Fe-dependent oxidative conditions in rat brain. This analysis shows that acute Fe-overload, seems to affect A● state concentration by a more complex pathway network than sub-chronic Fe-overload. The mechanistic study presented here will help to understand the mechanisms that govern the responses of living organisms to toxicologically relevant challenges.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
BP International  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ASCORBYL RADICAL  
dc.subject
BRAIN  
dc.subject
IRON OVERLOAD  
dc.subject
KINETIC MODEL  
dc.subject
OXIDATIVE STRESS  
dc.subject.classification
Otras Ciencias de la Salud  
dc.subject.classification
Ciencias de la Salud  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Fe overload an ascorbyl radical steady state concentration in rat brain  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.type
info:eu-repo/semantics/bookPart  
dc.type
info:ar-repo/semantics/parte de libro  
dc.date.updated
2023-07-05T12:22:05Z  
dc.journal.volume
4  
dc.journal.pagination
1-7  
dc.journal.pais
India  
dc.description.fil
Fil: Piloni, Natacha Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina  
dc.description.fil
Fil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.9734/bpi/idmmr/v4/3163E  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://stm.bookpi.org/IDMMR-V4/article/view/5538  
dc.conicet.paginas
172  
dc.source.titulo
Issues and Developments in Medicine and Medical Research