Mostrar el registro sencillo del ítem

dc.contributor.author
Lourido, Mercedes  
dc.contributor.author
Peluso, Julieta  
dc.contributor.author
Aronzon, Carolina Mariel  
dc.date.available
2023-07-17T18:42:22Z  
dc.date.issued
2022-01  
dc.identifier.citation
Lourido, Mercedes; Peluso, Julieta; Aronzon, Carolina Mariel; Lethal and sublethal effects of the emerging contaminant oxytetracycline on the embryo-larval development of Rhinella arenarum; Elsevier Science; Environmental Toxicology and Pharmacology; 89; 103783; 1-2022; 1-10  
dc.identifier.issn
1382-6689  
dc.identifier.uri
http://hdl.handle.net/11336/204232  
dc.description.abstract
The antibiotic oxytetracycline (OTC) is commonly used in animal production and can enter aquatic ecosystems, causing adverse effects on non-target species. The aim of this work was to evaluate the lethal and sublethal effects of OTC on the embryonic and larval period of Rhinella arenarum, through standardized bioassays and oxidative stress (catalase-CAT-, superoxide dismutase-SOD-, glutathione S-transferase-GST-, reduced glutathione-GSH- and lipid peroxidation-TBARS-), neurotoxicity (acetylcholinesterase-AChE- and butyrylcholinesterase-BChE-) and genotoxicity (micronuclei test) biomarkers. Mortality was time and stage dependent, being the embryos (504 h-LC50 = 64.04 mg/L) more sensitive than the larvae (504 h-LC50 = 97.74 mg/L). Alterations in the oxidative stress biomarkers were observed mainly in larvae: CAT, SOD and GST decreased and GSH increased significantly. In embryos, only GST decreased significantly. Also, OTC increased the AChE and BChE activities but did not increase the micronuclei frequency. This study shows evidence that the presence of OTC in the environment may have negative effects on amphibians.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
AMPHIBIANS  
dc.subject
BIOMARKERS  
dc.subject
EMERGING CONTAMINANTS  
dc.subject
OXYTETRACYCLINE  
dc.subject
STANDARDIZED BIOASSAYS  
dc.subject.classification
Otras Ciencias Biológicas  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Lethal and sublethal effects of the emerging contaminant oxytetracycline on the embryo-larval development of Rhinella arenarum  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-06-30T12:30:19Z  
dc.journal.volume
89  
dc.journal.number
103783  
dc.journal.pagination
1-10  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Lourido, Mercedes. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación e Ingeniería Ambiental; Argentina  
dc.description.fil
Fil: Peluso, Julieta. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación e Ingeniería Ambiental; Argentina  
dc.description.fil
Fil: Aronzon, Carolina Mariel. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación e Ingeniería Ambiental; Argentina  
dc.journal.title
Environmental Toxicology and Pharmacology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1382668921002015  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.etap.2021.103783