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Artículo

Metabolite transporters in trypanosomatid parasites: promising therapeutic targets but... How to deal with them?

Pereira, Claudio AlejandroIcon ; Martínez Sayé, Melisa SoledadIcon ; Wrenger, C.; Miranda, Mariana ReneéIcon
Fecha de publicación: 05/2014
Editorial: Bentham Science Publishers
Revista: Current Medicinal Chemistry
ISSN: 0929-8673
e-ISSN: 1875-533X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología Celular, Microbiología

Resumen

Infections caused by protozoan parasites are one of the most important public health problems in developing countries. One approach to design new drugs for these parasitic diseases relies on metabolic and molecular features which are ideally absent in mammalian hosts. Out of them, nutrient transporters play an important role since they were subjected to millions of years of adaptation to parasitism, in which this protozoan replaced many biosynthetic routes for transport systems. Here we address the current knowledge of trypanosomatids transport systems and the molecules related to such processes, including a description of permeases involved in drug uptake, and also those responsible of drug resistance. The latter process produces, in many cases, the treatment failure due to the loss of the transporter function, as is the case of eflornithine, as well as by increasing the extrusion of drugs, in which usually ABC-type transporters are involved. All these aspects and the perspectives on this topic are briefly updated in this review.
Palabras clave: Permeases , Transporters , Drug Resistence , Protozoan Parasites , Trypanosoma , Leishmania
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/20402
URL: http://www.eurekaselect.com/114575/article
DOI: http://dx.doi.org/10.2174/09298673113209990228
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Articulos de INST.DE INVEST.MEDICAS
Citación
Pereira, Claudio Alejandro; Martínez Sayé, Melisa Soledad; Wrenger, C.; Miranda, Mariana Reneé; Metabolite transporters in trypanosomatid parasites: promising therapeutic targets but... How to deal with them?; Bentham Science Publishers; Current Medicinal Chemistry; 21; 15; 5-2014; 1707-1712
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