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dc.contributor.author
Cremonini, Eleonora
dc.contributor.author
Iglesias, Dario Ezequiel
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dc.contributor.author
Matsukuma, Karen E.
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Hester, Shelly N.
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Wood, Steven M.
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Bartlett, Mark
dc.contributor.author
Fraga, César Guillermo
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dc.contributor.author
Oteiza, Patricia I.
dc.date.available
2023-07-14T11:56:46Z
dc.date.issued
2022-01
dc.identifier.citation
Cremonini, Eleonora; Iglesias, Dario Ezequiel; Matsukuma, Karen E.; Hester, Shelly N.; Wood, Steven M.; et al.; Supplementation with cyanidin and delphinidin mitigates high fat diet-induced endotoxemia and associated liver inflammation in mice; Royal Society of Chemistry; Food and Function; 13; 2; 1-2022; 781-794
dc.identifier.issn
2042-650X
dc.identifier.uri
http://hdl.handle.net/11336/203933
dc.description.abstract
Consumption of high fat diets (HFD) and the associated metabolic endotoxemia can initiate liver inflammation and lipid deposition that with time can progress to non-alcoholic fatty liver disease (NAFLD). We previously observed that 14 weeks supplementation with the anthocyanidins cyanidin and delphinidin mitigated HFD-induced metabolic endotoxemia and liver insulin resistance, steatosis, inflammation and oxidative stress. This work investigated if a 4-week supplementation of mice with a cyanidin- and delphinidin-rich extract (CDRE) could mitigate or reverse HFD (60% calories from lard fat)-induced liver steatosis and inflammation. After a first 4-weeks period on the HFD, mice showed increased endotoxemia and activation of liver proinflammatory signaling cascades. Supplementation with CDRE between weeks 4 and 8 did not mitigate liver steatosis or the altered lipid and glucose plasma levels. However, CDRE supplementation reverted HFD-induced metabolic endotoxemia, in parallel with the mitigation of the overexpression of hepatic TLR2 and TLR4, and of the activation of: (i) NF-κB, (ii) AP-1 and upstream mitogen-activated kinases p38 and ERK1/2, and (iii) HIF-1. Thus, even a short-term consumption of cyanidin and delphinidin could help mitigate the adverse consequences, i.e. metabolic endotoxemia and associated liver inflammation, triggered by the regular consumption of diets rich in fat.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society of Chemistry
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
FLAVONOIDS
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ANTIOXIDANTS
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INFLAMMATION
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OBESITY
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Supplementation with cyanidin and delphinidin mitigates high fat diet-induced endotoxemia and associated liver inflammation in mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-05T12:15:12Z
dc.journal.volume
13
dc.journal.number
2
dc.journal.pagination
781-794
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Cremonini, Eleonora. University of California at Davis; Estados Unidos
dc.description.fil
Fil: Iglesias, Dario Ezequiel. University of California at Davis; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.description.fil
Fil: Matsukuma, Karen E.. University of California at Davis; Estados Unidos
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Fil: Hester, Shelly N.. No especifíca;
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Fil: Wood, Steven M.. No especifíca;
dc.description.fil
Fil: Bartlett, Mark. No especifíca;
dc.description.fil
Fil: Fraga, César Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.description.fil
Fil: Oteiza, Patricia I.. University of California at Davis; Estados Unidos
dc.journal.title
Food and Function
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/d1fo03108b
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