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dc.contributor.author
Zaman, KH Ahammad Uz  
dc.contributor.author
Wu, Xiaohua  
dc.contributor.author
Sarotti, Ariel Marcelo  
dc.contributor.author
Cao, Shugeng  
dc.date.available
2023-07-13T18:52:28Z  
dc.date.issued
2022-03-25  
dc.identifier.citation
Zaman, KH Ahammad Uz; Wu, Xiaohua; Sarotti, Ariel Marcelo; Cao, Shugeng; New and bioactive polyketides from Hawaiian marine-derived fungus Trichoderma sp. FM652; Taylor & Francis Ltd; Natural Product Research; 36; 23; 25-3-2022; 5984-5990  
dc.identifier.issn
1478-6419  
dc.identifier.uri
http://hdl.handle.net/11336/203830  
dc.description.abstract
Two new sorbicillinoid derivatives (1 and 2), together with ten other related compounds (3–12) were isolated from a Hawaiian marine fungal strain Trichoderma sp. FM652. The structures of compounds 1 and 2, including the absolute configuration, were elucidated by extensive analysis of NMR spectroscopy, HRESIMS and electronic circular dichroism (ECD) data. Compounds 6–12 exhibited significant anti-proliferative activity against ovarian cancer cell line A2780, with the IC50 values ranging from 0.5 to 8.07 μM. Moreover, compounds 1, 7 and 8 showed significant inhibition against NF-κB with IC50 values of 13.83, 24.40 and 14.63 µM, respectively. Compounds 6, 9 and 12 also demonstrated moderate inhibitory activity against S. aureus and methicillin resistant S. aureus with the MIC values in the range of 10–40 μg/mL.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Taylor & Francis Ltd  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ANTIBACTERIAL  
dc.subject
ANTIPROLIFERATIVE  
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ECD  
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NF-ΚB  
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NMR  
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SORBICILLINOID  
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TRICHODERMA  
dc.subject.classification
Química Orgánica  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
New and bioactive polyketides from Hawaiian marine-derived fungus Trichoderma sp. FM652  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-07-10T10:41:17Z  
dc.journal.volume
36  
dc.journal.number
23  
dc.journal.pagination
5984-5990  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Zaman, KH Ahammad Uz. University Of Hawaii; Estados Unidos  
dc.description.fil
Fil: Wu, Xiaohua. University Of Hawaii; Estados Unidos  
dc.description.fil
Fil: Sarotti, Ariel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina  
dc.description.fil
Fil: Cao, Shugeng. University Of Hawaii; Estados Unidos  
dc.journal.title
Natural Product Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/14786419.2022.2056890  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1080/14786419.2022.2056890