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dc.contributor.author
Uz Zaman, KH Ahammad  
dc.contributor.author
Sarotti, Ariel Marcelo  
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Wu, Xiaohua  
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De Vine, Lela  
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Cao, Shugeng  
dc.date.available
2023-07-13T18:49:12Z  
dc.date.issued
2022-06  
dc.identifier.citation
Uz Zaman, KH Ahammad; Sarotti, Ariel Marcelo; Wu, Xiaohua; De Vine, Lela; Cao, Shugeng; Polyketides, diketopiperazines and an isochromanone from the marine-derived fungal strain Fusarium graminearum FM1010 from Hawaii; Pergamon-Elsevier Science Ltd; Phytochemistry; 198; 6-2022; 1-8  
dc.identifier.issn
0031-9422  
dc.identifier.uri
http://hdl.handle.net/11336/203826  
dc.description.abstract
The fungal strain Fusarium graminearum FM1010 was isolated from a shallow-water volcanic rock known as “live rock” at the Carl Smith Beach, Hilo, Hawaii. Eleven specialised metabolites, including two undescribed diketopiperazines, three undescribed polyketides, and one undescribed isochromanone, along with five known fusarielin derivatives were obtained from F. graminearum FM1010. The structures of the six undescribed compounds were elucidated by extensive analysis of NMR spectroscopy, HRESIMS, chemical reactions, and electronic circular dichroism (ECD) data. Kaneoheoic acids G-I showed mild inhibitory activity against S. aureus with the MIC values in the range of 20–40 μg/mL when assayed in combination with chloramphenicol (half of the MIC, 1 μg/mL), an FDA approved antibiotic. Kaneoheoic acid I exhibited both anti-proliferative activity against ovarian cancer cell line A2780 and TNF-α induced NF-κB inhibitory activity with the IC50 values of 18.52 and 15.86 μM, respectively.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ANTIBACTERIAL ACTIVITY  
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ANTIPROLIFERATIVE  
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DIKETOPIPERAZINES  
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FUSARIUM GRAMINEARUM  
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ISOCHROMANONE  
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NECTRIACEAE  
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NF-ΚB  
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NMR  
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POLYKETIDES  
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Química Orgánica  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Polyketides, diketopiperazines and an isochromanone from the marine-derived fungal strain Fusarium graminearum FM1010 from Hawaii  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-07-10T10:41:19Z  
dc.journal.volume
198  
dc.journal.pagination
1-8  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Uz Zaman, KH Ahammad. University Of Hawaii; Estados Unidos  
dc.description.fil
Fil: Sarotti, Ariel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina  
dc.description.fil
Fil: Wu, Xiaohua. University Of Hawaii; Estados Unidos  
dc.description.fil
Fil: De Vine, Lela. Columbia University; Estados Unidos  
dc.description.fil
Fil: Cao, Shugeng. University Of Hawaii; Estados Unidos  
dc.journal.title
Phytochemistry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0031942222000541  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.phytochem.2022.113138