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Artículo

Gamma band activity in the developing parafascicular nucleus

Kezunovic, Nebojsa; Hyde, James; Simon, Christen; Urbano Suarez, Francisco JoseIcon ; Williams, D. Keith; Garcia Rill, Edgar
Fecha de publicación: 02/2012
Editorial: American Physiological Society
Revista: Journal of Neurophysiology
ISSN: 0022-3077
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

The parafascicular nucleus (Pf) receives cholinergic input from the pedunculopontine nucleus, part of the reticular activating system involved in waking and rapid eye movement (REM) sleep, and sends projections to the cortex. We tested the hypothesis that Pf neurons fire maximally at gamma band frequency (30–90 Hz), that this mechanism involves high-threshold voltage-dependent P/Q- and N-type calcium channels, and that this activity is enhanced by the cholinergic agonist carbachol (CAR). Patch-clamped 9- to 25-day-old rat Pf neurons (n = 299) manifested a firing frequency plateau at gamma band when maximally activated (31.5 ± 1.5 Hz) and showed gamma oscillations when voltage-clamped at holding potentials above −20 mV, and the frequency of the oscillations increased significantly with age (24.6 ± 3.8 vs. 51.6 ± 4.4 Hz, P < 0.001) but plateaued at gamma frequencies. Cells exposed to CAR showed significantly higher frequencies early in development compared with those without CAR (24.6 ± 3.8 vs. 41.7 ± 4.3 Hz, P < 0.001) but plateaued with age. The P/Q-type calcium channel blocker ω-agatoxin-IVA (ω-Aga) blocked gamma oscillations, whereas the N-type blocker ω-conotoxin-GVIA (ω-CgTx) only partially decreased the power spectrum amplitude of gamma oscillations. The blocking effect of ω-Aga on P/Q-type currents and ω-CgTx on N-type currents was consistent over age. We conclude that P/Q- and N-type calcium channels appear to mediate Pf gamma oscillations during development. We hypothesize that the cholinergic input to the Pf could activate these cells to oscillate at gamma frequency, and perhaps relay these rhythms to cortical areas, thus providing a stable high-frequency state for “nonspecific” thalamocortical processing.
Palabras clave: Parafascicular , Arousal , Calcium Currents , Gamma Oscillations
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/20369
DOI: http://dx.doi.org/10.1152/jn.00677.2011
URL: http://jn.physiology.org/content/107/3/772
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289474/
Colecciones
Articulos(IFIBYNE)
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Citación
Kezunovic, Nebojsa; Hyde, James; Simon, Christen; Urbano Suarez, Francisco Jose; Williams, D. Keith; et al.; Gamma band activity in the developing parafascicular nucleus; American Physiological Society; Journal of Neurophysiology; 107; 3; 2-2012; 772-784
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