Artículo
Epigenetics in Alternative Pre-mRNA Splicing
Fecha de publicación:
01/2011
Editorial:
Cell Press
Revista:
Cell
ISSN:
0092-8674
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Alternative splicing plays critical roles in differentiation, development, and disease and is a major source for protein diversity in higher eukaryotes. Analysis of alternative splicing regulation has traditionally focused on RNA sequence elements and their associated splicing factors, but recent provocative studies point to a key function of chromatin structure and histone modifications in alternative splicing regulation. These insights suggest that epigenetic regulation determines not only what parts of the genome are expressed but also how they are spliced.
Palabras clave:
Epigenética
,
Splicing
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Colecciones
Articulos(IFIBYNE)
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Citación
Luco, Reini F.; Alló, Mariano; Schor, Ignacio Esteban; Kornblihtt, Alberto Rodolfo; Misteli, Tom; Epigenetics in Alternative Pre-mRNA Splicing; Cell Press; Cell; 144; 1; 1-2011; 16-26
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