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dc.contributor.author
Choi, Soonwook
dc.contributor.author
Yu, Eunah
dc.contributor.author
Kim, Daesoo
dc.contributor.author
Urbano Suarez, Francisco Jose
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Makarenko, Vladimir
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Shin, Hee Sup
dc.contributor.author
Llinás, Rodolfo R.
dc.date.available
2017-07-13T18:30:43Z
dc.date.issued
2010-08
dc.identifier.citation
Choi, Soonwook; Yu, Eunah; Kim, Daesoo; Urbano Suarez, Francisco Jose; Makarenko, Vladimir; et al.; Subthreshold membrane potential oscillations in inferior olive neurons are dynamically regulated by P/Q- and T-type calcium channels: a study in mutant mice; Wiley; The Journal Of Physiology; 588; 16; 8-2010; 3031-3043
dc.identifier.issn
0022-3751
dc.identifier.uri
http://hdl.handle.net/11336/20365
dc.description.abstract
The role of P/Q- and T-type calcium channels in the rhythmic oscillatory behaviour of inferior olive (IO) neurons was investigated in mutant mice. Mice lacking either the CaV2.1 gene of the pore-forming α1A subunit for P/Q-type calcium channel, or the CaV3.1 gene of the pore-forming α1G subunit for T-type calcium channel were used. In vitro intracellular recording from IO neurons reveals that the amplitude and frequency of sinusoidal subthreshold oscillations (SSTOs) were reduced in the CaV2.1−/− mice. In the CaV3.1−/− mice, IO neurons also showed altered patterns of SSTOs and the probability of SSTO generation was significantly lower (15%, 5 of 34 neurons) than that of wild-type (78%, 31 of 40 neurons) or CaV2.1−/− mice (73%, 22 of 30 neurons). In addition, the low-threshold calcium spike and the sustained endogenous oscillation following rebound potentials were absent in IO neurons from CaV3.1−/− mice. Moreover, the phase-reset dynamics of oscillatory properties of single neurons and neuronal clusters in IO were remarkably altered in both CaV2.1−/− and CaV3.1−/− mice. These results suggest that both α1A P/Q- and α1G T-type calcium channels are required for the dynamic control of neuronal oscillations in the IO. These findings were supported by results from a mathematical IO neuronal model that incorporated T and P/Q channel kinetics.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Inferior Olive
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Oscillations
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P/Q-Type; T-Type Calcium Channels
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Patch Clamp Slices
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Subthreshold membrane potential oscillations in inferior olive neurons are dynamically regulated by P/Q- and T-type calcium channels: a study in mutant mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-12T14:52:26Z
dc.journal.volume
588
dc.journal.number
16
dc.journal.pagination
3031-3043
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Choi, Soonwook. University of New York; Estados Unidos. University of Science and Technology; Corea del Sur
dc.description.fil
Fil: Yu, Eunah. University of New York; Estados Unidos
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Fil: Kim, Daesoo. Korea Advanced Institute of Science and Technology; Corea del Sur
dc.description.fil
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: Makarenko, Vladimir. University of New York; Estados Unidos
dc.description.fil
Fil: Shin, Hee Sup. University of Science and Technology; Corea del Sur
dc.description.fil
Fil: Llinás, Rodolfo R.. University of New York; Estados Unidos
dc.journal.title
The Journal Of Physiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1113/jphysiol.2009.184705
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2009.184705/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956943/
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