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dc.contributor.author
Fededa, Juan Pablo
dc.contributor.author
Gerlich, Daniel W.
dc.date.available
2017-07-13T15:16:55Z
dc.date.issued
2012-05
dc.identifier.citation
Fededa, Juan Pablo; Gerlich, Daniel W.; Molecular control of animal cell cytokinesis; Nature Publishing Group; Nature Cell Biology; 14; 5; 5-2012; 440-447
dc.identifier.issn
1465-7392
dc.identifier.uri
http://hdl.handle.net/11336/20338
dc.description.abstract
Cytokinesis is the process by which mitotic cells physically split in two following chromosome segregation. Dividing animal cells first ingress a cytokinetic furrow and then separate the plasma membrane by abscission. The general cytological events and several conserved molecular factors involved in cytokinesis have been known for many years. However, recent progress in microscopy, chemical genetics, biochemical reconstitution and biophysical methodology has tremendously increased our understanding of the underlying molecular mechanisms. We discuss how recent insights have led to refined models of the distinct steps of animal cell cytokinesis, including anaphase spindle reorganization, division plane specification, actomyosin ring assembly and contraction, and abscission. We highlight how molecular signalling pathways coordinate the individual events to ensure faithful partitioning of the genome to emerging daughter cells.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cytokinesis
dc.subject
Anaphase Spindle Reorganization
dc.subject
Actomyosin Ring Assembly
dc.subject
Abscission
dc.subject.classification
Biología Celular, Microbiología
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Molecular control of animal cell cytokinesis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-12T14:52:55Z
dc.identifier.eissn
1476-4679
dc.journal.volume
14
dc.journal.number
5
dc.journal.pagination
440-447
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Fededa, Juan Pablo. Swiss Federal Institute Of Technology Zurich; Suiza. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Gerlich, Daniel W.. Swiss Federal Institute Of Technology Zurich; Suiza
dc.journal.title
Nature Cell Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/ncb2482
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/ncb/journal/v14/n5/full/ncb2482.html
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