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dc.contributor.author
Cárdenas, Ana María
dc.contributor.author
Marengo, Fernando Diego
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dc.date.available
2017-07-13T15:15:55Z
dc.date.issued
2010-11
dc.identifier.citation
Cárdenas, Ana María; Marengo, Fernando Diego; Rapid Endocytosis and Vesicle Recycling in Neuroendocrine Cells; Springer; Cellular And Molecular Neurobiology.; 30; 8; 11-2010; 1365-1370
dc.identifier.issn
0272-4340
dc.identifier.uri
http://hdl.handle.net/11336/20331
dc.description.abstract
Endocytosis is a crucial process for neuroendocrine cells that ensures membrane homeostasis, vesicle recycling, and hormone release reliability. Different endocytic mechanisms have been described in chromaffin cells, such as clathrin-dependent slow endocytosis and clathrin-independent rapid endocytosis. Rapid endocytosis, classically measured in terms of a fast decrease in membrane capacitance, exhibits two different forms, ‘‘rapid compensatory endocytosis’’ and ‘‘excess retrieval.’’ While excess retrieval seems to be associated with formation of long-lasting endosomes, rapid compensatory endocytosis is well correlated with exocytotic activity, and it is regarded as a mechanism associated to rapid vesicle recycling during normal secretory activity. It has been suggested that rapid compensatory endocytosis may be related to the prevalence of a transient fusion mode of exo-endocytosis. In the latter mode, the fusion pore, a nanometric-sized channel formed at the onset of exocytosis, remains open for a few hundred milliseconds and later abruptly closes, releasing a small amount of transmitters. By this mechanism, endocrine cell selectively releases low molecular weight transmitters, and rapidly recycles the secretory vesicles. In this article, we discuss the cellular and molecular mechanisms that define the different forms of exocytosis and endocytosis and their impact on vesicle recycling pathways.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Exocytosis
dc.subject
Endocytosis
dc.subject
Secretory Vesicle
dc.subject
Recycling
dc.subject.classification
Fisiología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Rapid Endocytosis and Vesicle Recycling in Neuroendocrine Cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-12T14:52:17Z
dc.identifier.eissn
1573-6830
dc.journal.volume
30
dc.journal.number
8
dc.journal.pagination
1365-1370
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Cárdenas, Ana María. Universidad de Valparaíso. Centro Interdisciplinario de Neurociencia; Chile
dc.description.fil
Fil: Marengo, Fernando Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.journal.title
Cellular And Molecular Neurobiology.
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10571-010-9579-8
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs10571-010-9579-8
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