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dc.contributor.author Sicard, Flavie
dc.contributor.author Ehrhart Bornstein, Monika
dc.contributor.author Corbeil, Denis
dc.contributor.author Sperber, Simone
dc.contributor.author Krug, Alexander W.
dc.contributor.author Ziegler, Christian G.
dc.contributor.author Besuhli, Valeria
dc.contributor.author McCann, Samuel M.
dc.contributor.author Bornstein, Stefan R.
dc.date.available 2017-07-13T00:15:05Z
dc.date.issued 2007-12
dc.identifier.citation Sicard, Flavie; Ehrhart Bornstein, Monika; Corbeil, Denis; Sperber, Simone; Krug, Alexander W.; et al.; Age-dependent regulation of chromaffin cell proliferation by growth factors, dehydroepiandrosterone (DHEA), and DHEA sulfate; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 104; 6; 12-2007; 2007-2012
dc.identifier.issn 0027-8424
dc.identifier.uri http://hdl.handle.net/11336/20327
dc.description.abstract The adrenal gland comprises two endocrine tissues of distinct origin, the catecholamine-producing medulla and the steroid-producing cortex. The inner adrenocortical zone, which is in direct contact with the adrenomedullary chromaffin cells, produces dehydroepiandrostendione (DHEA) and DHEA sulfate (DHEAS). These two androgens exhibit potential effects on neurogenesis, neuronal survival, and neuronal stem cell proliferation. Unlike the closely related sympathetic neurons, chromaffin cells are able to proliferate throughout life. The aim of this study was to investigate the effect of DHEA and DHEAS on proliferation of bovine chromaffin cells from young and adult animals. We demonstrated that graded concentrations of leukemia inhibitory factor induced proliferation of chromaffin cells from young animals, whereas EGF had no effect. On the contrary, EGF increased the cell proliferation in cells from adult animals, whereas leukemia inhibitory factor was inactive. In both cases, DHEA decreased the proliferative effect induced by the growth factors. Surprisingly, DHEAS enhanced, in a dose-dependent-manner, the effect of growth factors on proliferation in cells from adult animals but not from young animals. Flutamide, ICI 182,780, and RU 486 had no effect on the action of DHEA or DHEAS on chromaffin cell proliferation. These data show that DHEA and its sulfated form, DHEAS, differentially regulate growth-factor-induced proliferation of bovine chromaffin cells. In addition, the sensitivity of chromaffin cells to different growth factors is age-dependent. Furthermore, these two androgens may act through a receptor other than the classical steroid receptors.
dc.format application/pdf
dc.language.iso eng
dc.publisher National Academy of Sciences
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject.classification Otras Ciencias Médicas
dc.subject.classification Otras Ciencias Médicas
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Age-dependent regulation of chromaffin cell proliferation by growth factors, dehydroepiandrosterone (DHEA), and DHEA sulfate
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-07-11T19:46:21Z
dc.journal.volume 104
dc.journal.number 6
dc.journal.pagination 2007-2012
dc.journal.pais Estados Unidos
dc.description.fil Fil: Sicard, Flavie. University of Technology; Alemania
dc.description.fil Fil: Ehrhart Bornstein, Monika. University of Technology; Alemania
dc.description.fil Fil: Corbeil, Denis. University of Technology; Alemania
dc.description.fil Fil: Sperber, Simone. University of Technology; Alemania
dc.description.fil Fil: Krug, Alexander W.. University of Technology; Alemania
dc.description.fil Fil: Ziegler, Christian G.. University of Technology; Alemania
dc.description.fil Fil: Besuhli, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil Fil: McCann, Samuel M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil Fil: Bornstein, Stefan R.. University of Technology; Alemania
dc.journal.title Proceedings of the National Academy of Sciences of The United States of America
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.pnas.org/content/104/6/2007.long
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1073/pnas.0610898104
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794270/


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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)