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Artículo

SLAM and CD31: signaling molecules involved in cytokine secretion during the development of innate and adaptive immune responses

García, Verónica EdithIcon ; Chuluyan, Hector EduardoIcon
Fecha de publicación: 02/2007
Editorial: Elsevier
Revista: Cytokine & Growth Factor Reviews
ISSN: 1359-6101
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

Immune cells are modulated through the crosslinking of receptors named “immunoreceptors”. Ligation of immunoreceptors by their ligands induces a tyrosine-phosphorylation signal that is essential for cell activation or inhibition. Physiologically, immunoreceptor triggering is not enough for cell activation, and stimulation of co-receptors is necessary for antigen-evoked cytokine production. Thus, signal transduction pathways mediated by proteins that regulate cytokine secretion are critical to achieve an effective immune response of the host, where the balance between positive and negative signaling allows effective immune responses, preventing tolerance and autoimmunity. This review deals with recent studies based on the role of the receptor signaling lymphocytic activation molecule (SLAM), a signaling protein that modulates cytokine secretion by immune cells, and the transmembrane glycoprotein CD31, which plays multiple roles in cellular signaling events by modulating the balance between inhibitory and stimulatory signals to immune cells. Recent studies have shed light on the ability of these molecules to transmit different signals that regulate the ability of innate and adaptive immune cells to synthesize stimulatory and inhibitory cytokines.
Palabras clave: Cytokines , Signaling Proteins , Cd31 , Slam , Immune Response
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/20324
URL: http://www.sciencedirect.com/science/article/pii/S1359610107000093
DOI: http://dx.doi.org/10.1016/j.cytogfr.2007.01.008
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Citación
García, Verónica Edith; Chuluyan, Hector Eduardo; SLAM and CD31: signaling molecules involved in cytokine secretion during the development of innate and adaptive immune responses; Elsevier; Cytokine & Growth Factor Reviews; 18; 1-2; 2-2007; 85-96
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