Artículo
Epigenetic Mechanisms Involved in Inflammaging-Associated Hypertension
Simão, Vinícius Augusto; Ferder, Leon Fernando; Manucha, Walter Ariel Fernando
; Chuffa, Luiz Gustavo
Fecha de publicación:
11/2022
Editorial:
Springer
Revista:
Current Hypertension Reports
ISSN:
1522-6417
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Purpose of Review: This review summarizes the involvement of inflammaging in vascular damage with focus on the epigenetic mechanisms by which inflammaging-induced hypertension is triggered. Recent Findings: Inflammaging in hypertension is a complex condition associated with the production of inflammatory mediators by the immune cells, enhancement of oxidative stress, and tissue remodeling in vascular smooth muscle cells and endothelial cells. Cellular processes are numerous, including inflammasome assembly and cell senescence which may involve mitochondrial dysfunction, autophagy, DNA damage response, dysbiosis, and many others. More recently, a series of noncoding RNAs, mainly microRNAs, have been described as possessing epigenetic actions on the regulation of inflammasome-related hypertension, emerging as a promising therapeutic strategy. Summary: Although there are a variety of pharmacological agents that effectively regulate inflammaging-related hypertension, a deeper understanding of the epigenetic events behind the control of vessel deterioration is needed for the treatment or even to prevent the disease onset.
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Articulos(IMBECU)
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Citación
Simão, Vinícius Augusto; Ferder, Leon Fernando; Manucha, Walter Ariel Fernando; Chuffa, Luiz Gustavo; Epigenetic Mechanisms Involved in Inflammaging-Associated Hypertension; Springer; Current Hypertension Reports; 24; 11; 11-2022; 547-562
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