Mostrar el registro sencillo del ítem

dc.contributor.author
Garcia Rill, E.  
dc.contributor.author
Kezunovic, N.  
dc.contributor.author
D'Onofrio, S.  
dc.contributor.author
Luster, B.  
dc.contributor.author
Hyde, J.  
dc.contributor.author
Bisagno, Veronica  
dc.contributor.author
Urbano Suarez, Francisco Jose  
dc.date.available
2017-07-12T22:20:20Z  
dc.date.issued
2014-05  
dc.identifier.citation
Garcia Rill, E.; Kezunovic, N.; D'Onofrio, S.; Luster, B.; Hyde, J.; et al.; Gamma band activity in the RAS-intracellular mechanism; Springer; Experimental Brain Research; 232; 5; 5-2014; 1509-1522  
dc.identifier.issn
0014-4819  
dc.identifier.uri
http://hdl.handle.net/11336/20321  
dc.description.abstract
Gamma band activity participates in sensory perception, problem solving, and memory. This review considers recent evidence showing that cells in the reticular activating system (RAS) exhibit gamma band activity, and describes the intrinsic membrane properties behind such manifestation. Specifically, we discuss how cells in the mesopontine pedunculopontine nucleus, intralaminar parafascicular nucleus, and pontine SubCoeruleus nucleus dorsalis all fire in the gamma band range when maximally activated, but no higher. The mechanisms involve high-threshold, voltage-dependent P/Q-type calcium channels, or sodium-dependent subthreshold oscillations. Rather than participating in the temporal binding of sensory events as in the cortex, gamma band activity in the RAS may participate in the processes of preconscious awareness and provide the essential stream of information for the formulation of many of our actions. We address three necessary next steps resulting from these discoveries: an intracellular mechanism responsible for maintaining gamma band activity based on persistent G-protein activation, separate intracellular pathways that differentiate between gamma band activity during waking versus during REM sleep, and an intracellular mechanism responsible for the dysregulation in gamma band activity in schizophrenia. These findings open several promising research avenues that have not been thoroughly explored. What are the effects of sleep or REM sleep deprivation on these RAS mechanisms? Are these mechanisms involved in memory processing during waking and/or during REM sleep? Does gamma band processing differ during waking versus REM sleep after sleep or REM sleep deprivation?  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Brainstem  
dc.subject
Modafinil  
dc.subject
Pedunculopontine  
dc.subject
Calcium Channels  
dc.subject.classification
Neurociencias  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Gamma band activity in the RAS-intracellular mechanism  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-07-11T13:25:50Z  
dc.identifier.eissn
1432-1106  
dc.journal.volume
232  
dc.journal.number
5  
dc.journal.pagination
1509-1522  
dc.journal.pais
Alemania  
dc.journal.ciudad
Berlin  
dc.description.fil
Fil: Garcia Rill, E.. University Of Arkansas For Medical Sciences; Estados Unidos  
dc.description.fil
Fil: Kezunovic, N.. University Of Arkansas For Medical Sciences; Estados Unidos  
dc.description.fil
Fil: D'Onofrio, S.. University Of Arkansas For Medical Sciences; Estados Unidos  
dc.description.fil
Fil: Luster, B.. University Of Arkansas For Medical Sciences; Estados Unidos  
dc.description.fil
Fil: Hyde, J.. University Of Arkansas For Medical Sciences; Estados Unidos  
dc.description.fil
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina  
dc.description.fil
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina  
dc.journal.title
Experimental Brain Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00221-013-3794-8  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00221-013-3794-8