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dc.contributor.author
Piriz, Joaquin  
dc.contributor.author
Muller, A.  
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Trejo, J. L.  
dc.contributor.author
Torres Aleman, I.  
dc.date.available
2017-07-12T20:33:35Z  
dc.date.issued
2010-09  
dc.identifier.citation
Piriz, Joaquin; Muller, A.; Trejo, J. L.; Torres Aleman, I.; IGF-I and the aging mammalian brain ; Elsevier Inc; Experimental Gerontology; 46; 2-3; 9-2010; 96-99  
dc.identifier.issn
0531-5565  
dc.identifier.uri
http://hdl.handle.net/11336/20274  
dc.description.abstract
Insulin-like growth factors (IGFs) are important modulators of organismal life-span all along phylogeny. These growth factors are widely viewed as detrimental for long life by reducing tissue resistance to oxidative stress. However, IGF-I has been consistently shown to be a potent neuroprotective factor in mammals, and as such, a deterrent of brain aging. Conversely, recent data suggest that IGF-I may contribute to amyloid neurodegeneration underlying Alzheimer's disease. These opposing observations underline an incomplete understanding of the significance of this ancestral hormone pathway in relation to brain aging. It is possible that these opposite results are the consequence of using different experimental approaches. Thus, brain amyloid injury is reduced in mutant mice partially defective in IGF-I receptor function, whereas IGF-I is neuroprotective when administered to animal models of neurodegenerative disease or normal brain aging. This approach-dependent effect of IGF-I highlights a fundamental gap in our knowledge of the relationship between peripheral and brain IGF-I function and the actual biological impact of experimental modulation of brain IGF-I function. We suggest to directly address brain IGF-I function in the varying experimental approaches used to confirm that changes have taken place in the desired way.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
Brain Aging  
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Neurotrophic Factors  
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Alzheimer'S Disease  
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Insulin-Like Growth Factor I  
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Neurociencias  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
IGF-I and the aging mammalian brain  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-07-12T14:52:50Z  
dc.journal.volume
46  
dc.journal.number
2-3  
dc.journal.pagination
96-99  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Piriz, Joaquin. Instituto Cajal; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Muller, A.. Instituto Cajal; España  
dc.description.fil
Fil: Trejo, J. L.. Instituto Cajal; España  
dc.description.fil
Fil: Torres Aleman, I.. Instituto Cajal; España  
dc.journal.title
Experimental Gerontology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.exger.2010.08.022  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0531556510002664