Artículo
Autoimmunity in Amyotrophic Lateral Sclerosis: Past and Present
Fecha de publicación:
06/2011
Editorial:
Hindawi Publishing Corporation
Revista:
Neurology Research International
ISSN:
2090-1852
e-ISSN:
2090-1860
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting particularly motor neurons for which no cure or effective treatment is available. Although the cause of ALS remains unknown, accumulative evidence suggests an autoimmune mechanism of pathogenesis. In this paper, we will summarize the current research related to autoimmunity in the sporadic form of ALS and discuss the potential underlying pathogenic mechanisms and perspectives. Presented data supports the view that humoral immune responses against motor nerve terminals can initiate a series of physiological changes leading to alteration of calcium homeostasis. In turn, loss of calcium homeostasis may induce neuronal death through apoptotic signaling pathways. Additional approaches identifying specific molecular features of this hypothesis are required, which will hopefully allow us to develop techniques of early diagnosis and effective therapies.
Palabras clave:
Autoimmunity
,
Amyotrophic
,
Lateral Sclerosis
,
Calcium Channels
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IFIBYNE)
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Citación
Pagani, Mario Rafael; Gonzalez, Laura Elisabeth; Uchitel, Osvaldo Daniel; Autoimmunity in Amyotrophic Lateral Sclerosis: Past and Present
; Hindawi Publishing Corporation; Neurology Research International; 2011; 6-2011; 1-11; 497080
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