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dc.contributor.author
Frechtel, Gustavo Daniel
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dc.contributor.author
Forti, Lujan
dc.contributor.author
Faingold, María Cristina
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dc.contributor.author
Perez Mangui, Federico
dc.contributor.author
Orio, Silvia
dc.contributor.author
Issa, Claudia
dc.contributor.author
Guaita, María Silvina
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dc.contributor.author
Vivas, Norma
dc.contributor.author
De Luca, Julian A.
dc.date.available
2023-07-05T15:09:05Z
dc.date.issued
2021-01
dc.identifier.citation
Frechtel, Gustavo Daniel; Forti, Lujan; Faingold, María Cristina; Perez Mangui, Federico; Orio, Silvia; et al.; A study to assess the unmet medical needs associated with the use of basal insulin in patients with type 2 diabetes; Blackwell Publishing; Endocrinology, Diabetes and Metabolism; 4; 1; 1-2021; 1-10
dc.identifier.issn
2398-9238
dc.identifier.uri
http://hdl.handle.net/11336/202468
dc.description.abstract
Aim: To describe in a real-world setting, the proportion of patients with a symptomatic hypoglycaemic event and the proportion of individuals with type 2 diabetes, who newly or recently initiated with basal insulin, achieving individual or general HbA1c target. Materials and Method: DINAS-AR was a national prospective observational study to assess the unmet needs in patients with type 2 diabetes treated with basal insulin with or without oral antihyperglycaemic drugs and/or GLP-1 receptor agonist. The study was conducted at 19 hospitals. Results: A total of 385 uncontrolled patients (≥18 years) who recently initiated basal insulin or who initiated treatment within a year prior to study enrolment entered the study. Outcomes were follow-up incidence of hypoglycaemic events, change of HbA1C and achievement of HBA1c <7% or individual target. A total of 44 patients (11.9%) reported the occurrence of ≥1 symptomatic hypoglycaemia event(s). HbA1c reductions were greater in patients who had recently initiated treatment with basal insulin (between 15 and 90 days prior to study entry) vs patients who initiated treatment within 1 year. A total of 80 patients (31.6%) achieved individual HbA1c target (or target <7.0%) at Week 24. Furthermore, the proportion of patients achieving this target without symptomatic hypoglycaemia was 26.1% (n = 66). A lower percentage of glycemia target achievement was observed in patients reporting hypoglycaemia (n = 14), 20.6% of all patients reporting hypoglycaemia event(s) vs (n = 66) 35.7% of all patients without hypoglycaemia event reported. Conclusion: In this real-world study, although the hypoglycaemia rate was not high in adults with type 2 diabetes treated with insulin, there was a lower percentage of patients that achieved glycemic target among those reporting hypoglycaemia events vs patients who did not report them.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Blackwell Publishing
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
BASAL INSULIN
dc.subject
HBA1C
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HYPOGLYCAEMIA
dc.subject
TYPE 2 DIABETES
dc.subject.classification
Endocrinología y Metabolismo
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
A study to assess the unmet medical needs associated with the use of basal insulin in patients with type 2 diabetes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-06-28T15:24:36Z
dc.journal.volume
4
dc.journal.number
1
dc.journal.pagination
1-10
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Frechtel, Gustavo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
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Fil: Forti, Lujan. Sanofi Aventis Argentina Sociedad Anonima.; Argentina
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Fil: Faingold, María Cristina. Unidad Asistencial "Dr. César Milstein"; Argentina
dc.description.fil
Fil: Perez Mangui, Federico. Centro de Investigaciones Metabólicas; Argentina
dc.description.fil
Fil: Orio, Silvia. No especifíca;
dc.description.fil
Fil: Issa, Claudia. Sanatorio Guemes Sociedad Anonima.; Argentina
dc.description.fil
Fil: Guaita, María Silvina. Sanofi Aventis Argentina Sociedad Anonima.; Argentina
dc.description.fil
Fil: Vivas, Norma. Sanofi Aventis Argentina Sociedad Anonima.; Argentina
dc.description.fil
Fil: De Luca, Julian A.. Sanofi Aventis Argentina Sociedad Anonima.; Argentina
dc.journal.title
Endocrinology, Diabetes and Metabolism
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/edm2.164
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