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dc.contributor.author
Asatryan, Aram
dc.contributor.author
Calandria, Jorgelina M.
dc.contributor.author
Kautzmann, Marie-Audrey
dc.contributor.author
Jun, Bokkyoo
dc.contributor.author
Gordon, William C.
dc.contributor.author
Do, Khanh V
dc.contributor.author
Bhattacharjee, S.
dc.contributor.author
Pham, Thang L.
dc.contributor.author
Bermúdez, Vicente
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dc.contributor.author
Mateos, Melina Valeria
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dc.contributor.author
Heap, Jessica
dc.contributor.author
Bazan, Nicolás G.
dc.date.available
2023-07-04T15:54:53Z
dc.date.issued
2022-06-30
dc.identifier.citation
Asatryan, Aram; Calandria, Jorgelina M.; Kautzmann, Marie-Audrey; Jun, Bokkyoo; Gordon, William C.; et al.; New Retinal Pigment Epithelial Cell Model to Unravel Neuroprotection Sensors of Neurodegeneration in Retinal Disease; Frontiers Media; Frontiers in Neuroscience; 16; 926629; 30-6-2022; 1-18
dc.identifier.uri
http://hdl.handle.net/11336/202305
dc.description.abstract
Retinal pigment epithelial (RPE) cells sustain photoreceptor integrity, and when this function is disrupted, retinal degenerations ensue. Herein, we characterize a new cell line from human RPE that we termed ABC. These cells remarkably recapitulate human eye native cells. Distinctive from other epithelia, RPE cells originate from the neural crest and follow a neural development but are terminally differentiated into “epithelial” type, thus sharing characteristics with their neuronal lineages counterparts. Additionally, they form microvilli, tight junctions, and honeycomb packing and express distinctive markers. In these cells, outer segment phagocytosis, phagolysosome fate, phospholipid metabolism, and lipid mediator release can be studied. ABC cells display higher resistance to oxidative stress and are protected from senescence through mTOR inhibition, making them more stable in culture. The cells are responsive to Neuroprotectin D1 (NPD1), which downregulates inflammasomes and upregulates antioxidant and anti-inflammatory genes. ABC gene expression profile displays close proximity to native RPE lineage, making them a reliable cell system to unravel signaling in uncompensated oxidative stress (UOS) and retinal degenerative disease to define neuroprotection sites.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AGE-RELATED MACULAR DEGENERATION (AMD)
dc.subject
APOPTOSIS
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AUTOPHAGY
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GENE EXPRESSION
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LIPIDS
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NEUROPROTECTIN D1
dc.subject
RPE CELL
dc.subject
SINGLE CELL
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
New Retinal Pigment Epithelial Cell Model to Unravel Neuroprotection Sensors of Neurodegeneration in Retinal Disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-06-29T17:49:25Z
dc.identifier.eissn
1662-453X
dc.journal.volume
16
dc.journal.number
926629
dc.journal.pagination
1-18
dc.journal.pais
Suiza
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dc.description.fil
Fil: Asatryan, Aram. State University of Louisiana; Estados Unidos
dc.description.fil
Fil: Calandria, Jorgelina M.. State University of Louisiana; Estados Unidos
dc.description.fil
Fil: Kautzmann, Marie-Audrey. State University of Louisiana; Estados Unidos
dc.description.fil
Fil: Jun, Bokkyoo. State University of Louisiana; Estados Unidos
dc.description.fil
Fil: Gordon, William C.. State University of Louisiana; Estados Unidos
dc.description.fil
Fil: Do, Khanh V. State University of Louisiana; Estados Unidos
dc.description.fil
Fil: Bhattacharjee, S.. State University of Louisiana; Estados Unidos
dc.description.fil
Fil: Pham, Thang L.. State University of Louisiana; Estados Unidos
dc.description.fil
Fil: Bermúdez, Vicente. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
dc.description.fil
Fil: Mateos, Melina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
dc.description.fil
Fil: Heap, Jessica. State University of Louisiana; Estados Unidos
dc.description.fil
Fil: Bazan, Nicolás G.. State University of Louisiana; Estados Unidos
dc.journal.title
Frontiers in Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnins.2022.926629/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fnins.2022.926629
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