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dc.contributor.author
Pittman, Ella
dc.contributor.author
Martin-Flores, Manuel
dc.contributor.author
Mosing, Martina
dc.contributor.author
Lorenzutti, Augusto Matías
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dc.contributor.author
Retamal, Jaime
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Staffieri, Francesco
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Adler, Andy
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Campbell, Mark
dc.contributor.author
Araos, Joaquin
dc.date.available
2023-07-04T14:04:59Z
dc.date.issued
2022-11
dc.identifier.citation
Pittman, Ella; Martin-Flores, Manuel; Mosing, Martina; Lorenzutti, Augusto Matías; Retamal, Jaime; et al.; Preliminary evaluation of the effects of a 1:1 inspiratory-to-expiratory ratio in anesthetized and ventilated horses; Wiley Blackwell Publishing, Inc; Veterinary Anaesthesia And Analgesia; 49; 6; 11-2022; 645-649
dc.identifier.issn
1467-2987
dc.identifier.uri
http://hdl.handle.net/11336/202246
dc.description.abstract
To describe some cardiorespiratory effects of an inspiratory-to-expiratory (IE) ratio of 1:1 compared with 1:3 in ventilated horses in dorsal recumbency. Study design: Randomized crossover experimental study. Animals: A total of eight anesthetized horses, with 444 (330–485) kg body weight [median (range)]. Methods: Horses were ventilated in dorsal recumbency with a tidal volume of 15 mL kg–1 and a respiratory rate of 8 breaths minute–1, and IE ratios of 1:1 (IE1:1) and 1:3 (IE1:3) in random order, each for 25 minutes after applying a recruitment maneuver. Spirometry, arterial blood gases and dobutamine requirements were recorded in all horses during each treatment. Electrical impedance tomography (EIT) data were recorded in four horses and used to generate functional EIT variables including regional ventilation delay index (RVD), a measure of speed of lung inflation, and end-expiratory lung impedance (EELI), an indicator of functional residual capacity (FRC). Results were assessed with linear and generalized linear mixed models. Results: Compared with treatment IE1:3, horses ventilated with treatment IE1:1 had higher mean airway pressures and respiratory system compliance (p < 0.014), while peak, end-inspiratory and driving airway pressures were lower (p < 0.001). No differences in arterial oxygenation or dobutamine requirements were observed. PaCO2 was lower in treatment IE1:1 (p = 0.039). Treatment IE1:1 resulted in lower RVD (p < 0.002) and higher EELI (p = 0.023) than treatment IE1:3. Conclusions and clinical relevance: These results suggest that IE1:1 improved respiratory system mechanics and alveolar ventilation compared with IE1:3, whereas oxygenation and dobutamine requirements were unchanged, although differences were small. In the four horses where EIT was evaluated, IE1:1 led to a faster inflation rate of the lung, possibly the result of increased FRC. The clinical relevance of these findings needs to be further investigated.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ELECTRICAL IMPEDANCE TOMOGRAPHY IN HORSES
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EQUINE MECHANICAL VENTILATION
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EQUINE RESPIRATORY MECHANICS
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INSPIRATORY-TO-EXPIRATORY RATIOS
dc.subject.classification
Otras Ciencias Veterinarias
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dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
Preliminary evaluation of the effects of a 1:1 inspiratory-to-expiratory ratio in anesthetized and ventilated horses
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-04T10:58:10Z
dc.identifier.eissn
1467-2995
dc.journal.volume
49
dc.journal.number
6
dc.journal.pagination
645-649
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Pittman, Ella. Cornell University College Of Veterinary Medicine; Estados Unidos
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Fil: Martin-Flores, Manuel. Cornell University College Of Veterinary Medicine; Estados Unidos
dc.description.fil
Fil: Mosing, Martina. Murdoch University; Australia
dc.description.fil
Fil: Lorenzutti, Augusto Matías. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; Argentina
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Fil: Retamal, Jaime. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: Staffieri, Francesco. Università degli Studi di Bari; Italia
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Fil: Adler, Andy. Carleton University; Canadá
dc.description.fil
Fil: Campbell, Mark. Carleton University; Canadá
dc.description.fil
Fil: Araos, Joaquin. Cornell University College Of Veterinary Medicine; Estados Unidos
dc.journal.title
Veterinary Anaesthesia And Analgesia
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.vaa.2022.07.009
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.vaajournal.org/article/S1467-2987(22)00126-X/fulltext
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