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dc.contributor.author
Camorani, Simona
dc.contributor.author
D'Argenio, Annachiara
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Agnello, Lisa
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Nilo, Roberto
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Zanetti, Antonella
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Ibarra, Luis Exequiel
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Fedele, Monica
dc.contributor.author
Cerchia, Laura
dc.date.available
2023-07-03T17:07:24Z
dc.date.issued
2022-04
dc.identifier.citation
Camorani, Simona; D'Argenio, Annachiara; Agnello, Lisa; Nilo, Roberto; Zanetti, Antonella; et al.; Optimization of Short RNA Aptamers for TNBC Cell Targeting; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 23; 7; 4-2022; 1-18
dc.identifier.issn
1422-0067
dc.identifier.uri
http://hdl.handle.net/11336/202077
dc.description.abstract
Triple-negative breast cancer (TNBC) is an aggressive cancer with limited targeted therapies. RNA aptamers, suitably chemically modified, work for therapeutic purposes in the same way as antibodies. We recently generated 2′ Fluoro-pyrimidines RNA-aptamers that act as effective recognition elements for functional surface signatures of TNBC cells. Here, we optimized three of them by shortening and proved the truncated aptamers as optimal candidates to enable active targeting to TNBC. By using prediction of secondary structure to guide truncation, we identified structural regions that account for the binding motifs of the full-length aptamers. Their chemical synthesis led to short aptamers with superb nuclease resistance, which specifically bind to TNBC target cells and rapidly internalize into acidic compartments. They interfere with the growth of TNBC cells as mammospheres, thus confirming their potential as anti-tumor agents. We propose sTN145, sTN58 and sTN29 aptamers as valuable tools for selective TNBC targeting and promising candidates for effective treatments, including therapeutic agents and targeted delivery nanovectors.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Molecular Diversity Preservation International
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ACTIVE TARGETING
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APTAMER STRUCTURES
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RNA APTAMER
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TNBC
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Otras Ciencias Médicas
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Otras Ciencias Médicas
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Optimization of Short RNA Aptamers for TNBC Cell Targeting
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-03T15:37:58Z
dc.identifier.eissn
1422-0067
dc.journal.volume
23
dc.journal.number
7
dc.journal.pagination
1-18
dc.journal.pais
Suiza
dc.journal.ciudad
Basel
dc.description.fil
Fil: Camorani, Simona. Institute Of Experimental Endocrinology And Oncology; Italia
dc.description.fil
Fil: D'Argenio, Annachiara. Institute Of Experimental Endocrinology And Oncology; Italia
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Fil: Agnello, Lisa. Institute Of Experimental Endocrinology And Oncology; Italia
dc.description.fil
Fil: Nilo, Roberto. Institute Of Experimental Endocrinology And Oncology; Italia
dc.description.fil
Fil: Zanetti, Antonella. Institute Of Biostructures And Bioimaging; Italia
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Fil: Ibarra, Luis Exequiel. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina
dc.description.fil
Fil: Fedele, Monica. Institute Of Experimental Endocrinology And Oncology; Italia
dc.description.fil
Fil: Cerchia, Laura. Institute Of Experimental Endocrinology And Oncology; Italia
dc.journal.title
International Journal of Molecular Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/23/7/3511
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/ijms23073511
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