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dc.contributor.author Garcia Rill, E.
dc.contributor.author Hyde, J.
dc.contributor.author Kezunovic, N.
dc.contributor.author Urbano Suarez, Francisco Jose
dc.contributor.author Petersen, E.
dc.date.available 2017-07-11T21:46:06Z
dc.date.issued 2015-02
dc.identifier.citation Garcia Rill, E.; Hyde, J.; Kezunovic, N.; Urbano Suarez, Francisco Jose; Petersen, E.; The physiology of the pedunculopontine nucleus: implications for deep brain stimulation; Springer Wien; Journal Of Neural Transmission. General Section.; 122; 2; 2-2015; 225-235
dc.identifier.issn 0300-9564
dc.identifier.uri http://hdl.handle.net/11336/20204
dc.description.abstract This brief review resolves a number of persistent conflicts regarding the location and characteristics of the mesencephalic locomotor region, which has in the past been described as not locomotion-specific and is more likely the pedunculopontine nucleus (PPN). The parameters of stimulation used to elicit changes in posture and locomotion we now know are ideally suited to match the intrinsic membrane properties of PPN neurons. The physiology of these cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target for the treatment of gait and postural deficits in Parkinson’s disease (PD). The discussion explains many of the effects reported following deep brain stimulation (DBS) of the PPN by different groups and provides guidelines for the determination of long-term assessment and effects of PPN DBS. A greater understanding of the physiology of the target nuclei within the brainstem and basal ganglia, amassed over the past decades, has enabled increasingly better patient outcomes from DBS for movement disorders. Despite these improvements, there remains a great opportunity for further understanding of the mechanisms through which DBS has its effects and for further development of appropriate technology to effect these treatments. We review the scientific basis for one of the newest targets, the PPN, in the treatment of PD and other movement disorders, and address the needs for further investigation.
dc.format application/pdf
dc.language.iso eng
dc.publisher Springer Wien
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject PEDUNCULOPONTINE
dc.subject BRAINSTEM
dc.subject DEEP BRAIN STIMULATION
dc.subject GAMMA BAND OSCILLATIONS
dc.subject CALCIUM CHANNELS
dc.subject.classification Neurociencias
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title The physiology of the pedunculopontine nucleus: implications for deep brain stimulation
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-07-11T19:27:36Z
dc.identifier.eissn 1435-1463
dc.journal.volume 122
dc.journal.number 2
dc.journal.pagination 225-235
dc.journal.pais Austria
dc.journal.ciudad Viena
dc.description.fil Fil: Garcia Rill, E.. University Of Arkansas For Medical Sciences; Estados Unidos
dc.description.fil Fil: Hyde, J.. University Of Arkansas For Medical Sciences; Estados Unidos
dc.description.fil Fil: Kezunovic, N.. University Of Arkansas For Medical Sciences; Estados Unidos
dc.description.fil Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil Fil: Petersen, E.. University Of Arkansas For Medical Sciences; Estados Unidos
dc.journal.title Journal Of Neural Transmission. General Section.
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00702-014-1243-x
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00702-014-1243-x


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)