Mostrar el registro sencillo del ítem
dc.contributor.author
Lee, Boyeon
dc.contributor.author
Pine, Michelle
dc.contributor.author
Johnson, Larry
dc.contributor.author
Besuhli, Valeria
dc.contributor.author
Hiney, Jill K.
dc.contributor.author
Les Dees, W.
dc.date.available
2017-07-11T21:36:39Z
dc.date.issued
2006-11
dc.identifier.citation
Lee, Boyeon; Pine, Michelle; Johnson, Larry; Besuhli, Valeria; Hiney, Jill K.; et al.; Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats; Elsevier Inc; Reproductive Toxicology; 22; 4; 11-2006; 580-585
dc.identifier.issn
0890-6238
dc.identifier.uri
http://hdl.handle.net/11336/20198
dc.description.abstract
Manganese (Mn) is an important element for normal growth and reproduction. Because Mn accumulates in the hypothalamus and is capable of stimulating puberty-related hormones in female rats, we assessed whether this metal could cause similar effects in male rats. We have demonstrated that MnCl2, when administered acutely into the third ventricle of the brain, acts dose dependently to stimulate luteinizing hormone (LH) release. Furthermore, there was a dose dependent stimulation in the secretion of LH-releasing hormone (LHRH) from the medial basal hypothalamus in vitro, and administration of an LHRH receptor antagonist in vivo blocks Mn-induced LH release. To assess potential chronic effects of the metal, male pups were supplemented with 10 or 25 mg MnCl2 per kg by gastric gavage from day 15 until days 48 or 55, at which times developmental signs of spermatogenesis were assessed. Results demonstrate that while significant effects were not observed with the 10 mg/kg dose, the animals receiving the 25 mg/kg dose showed increased LH (p < 0.05), FSH (p < 0.01) and testosterone (p < 0.01) levels at 55 days of age. Furthermore, there was a concomitant increase in both daily sperm production (p < 0.05) and efficiency of spermatogenesis (p < 0.05), demonstrating a Mn-induced acceleration in spermatogenesis. Our results suggest Mn is a stimulator of prepubertal LHRH/LH secretion and may facilitate the normal onset of male puberty. These data also suggest that the metal may contribute to male precocious pubertal development should an individual be exposed to low but elevated levels of Mn too early in life.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Puberty
dc.subject
Manganese
dc.subject
Luteinizing Hormone
dc.subject
Hypothalamus
dc.subject
Precocious Puberty
dc.subject
Spermatogenesis
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-11T19:46:09Z
dc.journal.volume
22
dc.journal.number
4
dc.journal.pagination
580-585
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Lee, Boyeon. Texas A&M University; Estados Unidos
dc.description.fil
Fil: Pine, Michelle. Texas A&M University; Estados Unidos
dc.description.fil
Fil: Johnson, Larry. Texas A&M University; Estados Unidos
dc.description.fil
Fil: Besuhli, Valeria. Texas A&M University; Estados Unidos
dc.description.fil
Fil: Hiney, Jill K.. Texas A&M University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Les Dees, W.. Texas A&M University; Estados Unidos
dc.journal.title
Reproductive Toxicology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0890623806000827
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.reprotox.2006.03.011
Archivos asociados