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dc.contributor.author
Muzzio, María Luz
dc.contributor.author
Miksztowicz, Verónica Julieta
dc.contributor.author
Brites, Fernando Daniel
dc.contributor.author
Aguilar Martinez, Daniel
dc.contributor.author
Repetto, Esteban Martin
dc.contributor.author
Wikinski, Regina
dc.contributor.author
Tavella, Marcelo Andres
dc.contributor.author
Schreier, Laura Ester
dc.contributor.author
Berg, Gabriela Alicia
dc.date.available
2017-07-11T21:31:33Z
dc.date.issued
2009-01
dc.identifier.citation
Muzzio, María Luz; Miksztowicz, Verónica Julieta; Brites, Fernando Daniel; Aguilar Martinez, Daniel; Repetto, Esteban Martin; et al.; Metalloproteases 2 and 9, Lp-PLA2 and lipoprotein profile in coronary patients; Elsevier Inc; Archives Of Medical Research (eletronico); 40; 1; 1-2009; 48-53
dc.identifier.issn
0188-4409
dc.identifier.uri
http://hdl.handle.net/11336/20194
dc.description.abstract
Background and Aims: Many studies suggest that the different steps of the atherosclerotic process may be mediated by metalloproteases (MMPs). MMP-9 and MMP-2, which are highly expressed in the vulnerable regions of the atherosclerotic plaques, have been suggested to be causally involved in plaque rupture. In another manner linked with LDL, lipoprotein-associated phospholipase A2 (Lp-PLA2) hydrolyzes phospholipids generating proinflammatory and proatherogenic products. Our aim was to evaluate plasma activity of MMP-2 and 9, as well as Lp-PLA2, in subjects with coronary artery stenosis in comparison with controls and to correlate these activities with lipoprotein profile and general biomarkers of inflammation. Methods: Forty two subjects who had undergone coronary angiography were divided into two groups: patients with coronary vessels with at least 45% stenosis (CAD [coronary artery disease], n = 24) and patients without angiographically detectable coronary artery disease (controls, n = 18). Plasma activity of MMP-2 and MMP-9 was measured and correlated with markers of systemic inflammation (hs-CRP), subendothelial inflammation (Lp-PLA2) and lipoprotein profile. Results: Plasma activity of both MMPs was consistently higher in patients than in controls (p <0.01). Pro-MMP-2 (r = 0.34, p <0.01) and MMP-9 (r = 0.51, p <0.02) activities correlated with apoprotein B. Pro-MMP-2 correlated with hs-CRP (r = 0.47, p <0.01) and inversely with HDL cholesterol (r = –0.35, p <0.02). No differences were observed in Lp-PLA2 between patients and controls (15.2 ± 4.0 vs. 15.4 ± 4.5 μmol/mL/h, p = NS, respectively), and no correlation was observed with MMPs. Conclusions: MMP activity was higher in CAD than in controls. The correlation observed between pro-MMP-2 and high-sensitive C-reactive protein (hs-CRP) may be due to specific systemic inflammatory processes. No correlation was observed between Lp-PLA2 and MMPs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Metalloproteases
dc.subject
Plaque Vulnerability
dc.subject
Lp-Pla2 Lipoproteins
dc.subject.classification
Fisiología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Metalloproteases 2 and 9, Lp-PLA2 and lipoprotein profile in coronary patients
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-11T19:46:42Z
dc.journal.volume
40
dc.journal.number
1
dc.journal.pagination
48-53
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Muzzio, María Luz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Miksztowicz, Verónica Julieta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Aguilar Martinez, Daniel. Universidad Nacional de La Plata; Argentina
dc.description.fil
Fil: Repetto, Esteban Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Wikinski, Regina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Tavella, Marcelo Andres. Universidad Nacional de La Plata; Argentina
dc.description.fil
Fil: Schreier, Laura Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Archives Of Medical Research (eletronico)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0188440908002567
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.arcmed.2008.10.011


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