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dc.contributor.author Muzzio, María Luz
dc.contributor.author Miksztowicz, Verónica Julieta
dc.contributor.author Brites, Fernando Daniel
dc.contributor.author Aguilar Martinez, Daniel
dc.contributor.author Repetto, Esteban Martin
dc.contributor.author Wikinski, Regina
dc.contributor.author Tavella, Marcelo Andres
dc.contributor.author Schreier, Laura Ester
dc.contributor.author Berg, Gabriela Alicia
dc.date.available 2017-07-11T21:31:33Z
dc.date.issued 2009-01
dc.identifier.citation Muzzio, María Luz; Miksztowicz, Verónica Julieta; Brites, Fernando Daniel; Aguilar Martinez, Daniel; Repetto, Esteban Martin; et al.; Metalloproteases 2 and 9, Lp-PLA2 and lipoprotein profile in coronary patients; Elsevier Inc; Archives Of Medical Research (eletronico); 40; 1; 1-2009; 48-53
dc.identifier.issn 0188-4409
dc.identifier.uri http://hdl.handle.net/11336/20194
dc.description.abstract Background and Aims: Many studies suggest that the different steps of the atherosclerotic process may be mediated by metalloproteases (MMPs). MMP-9 and MMP-2, which are highly expressed in the vulnerable regions of the atherosclerotic plaques, have been suggested to be causally involved in plaque rupture. In another manner linked with LDL, lipoprotein-associated phospholipase A2 (Lp-PLA2) hydrolyzes phospholipids generating proinflammatory and proatherogenic products. Our aim was to evaluate plasma activity of MMP-2 and 9, as well as Lp-PLA2, in subjects with coronary artery stenosis in comparison with controls and to correlate these activities with lipoprotein profile and general biomarkers of inflammation. Methods: Forty two subjects who had undergone coronary angiography were divided into two groups: patients with coronary vessels with at least 45% stenosis (CAD [coronary artery disease], n = 24) and patients without angiographically detectable coronary artery disease (controls, n = 18). Plasma activity of MMP-2 and MMP-9 was measured and correlated with markers of systemic inflammation (hs-CRP), subendothelial inflammation (Lp-PLA2) and lipoprotein profile. Results: Plasma activity of both MMPs was consistently higher in patients than in controls (p <0.01). Pro-MMP-2 (r = 0.34, p <0.01) and MMP-9 (r = 0.51, p <0.02) activities correlated with apoprotein B. Pro-MMP-2 correlated with hs-CRP (r = 0.47, p <0.01) and inversely with HDL cholesterol (r = –0.35, p <0.02). No differences were observed in Lp-PLA2 between patients and controls (15.2 ± 4.0 vs. 15.4 ± 4.5 μmol/mL/h, p = NS, respectively), and no correlation was observed with MMPs. Conclusions: MMP activity was higher in CAD than in controls. The correlation observed between pro-MMP-2 and high-sensitive C-reactive protein (hs-CRP) may be due to specific systemic inflammatory processes. No correlation was observed between Lp-PLA2 and MMPs.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier Inc
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Metalloproteases
dc.subject Plaque vulnerability
dc.subject Lp-PLA2 lipoproteins
dc.subject.classification Fisiología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Metalloproteases 2 and 9, Lp-PLA2 and lipoprotein profile in coronary patients
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-07-11T19:46:42Z
dc.journal.volume 40
dc.journal.number 1
dc.journal.pagination 48-53
dc.journal.pais Estados Unidos
dc.description.fil Fil: Muzzio, María Luz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil Fil: Miksztowicz, Verónica Julieta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Aguilar Martinez, Daniel. Universidad Nacional de La Plata; Argentina
dc.description.fil Fil: Repetto, Esteban Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Wikinski, Regina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil Fil: Tavella, Marcelo Andres. Universidad Nacional de La Plata; Argentina
dc.description.fil Fil: Schreier, Laura Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil Fil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title Archives Of Medical Research (eletronico)
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0188440908002567
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.arcmed.2008.10.011


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)