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dc.contributor.author
Perdomo González, Davinia Isabel
dc.contributor.author
Laseca, Nora
dc.contributor.author
Demyda-peyrás, Sebastian
dc.contributor.author
Valera, Mercedes
dc.contributor.author
Cervantes, Isabel
dc.contributor.author
Molina, Antonio
dc.date.available
2023-06-30T16:41:34Z
dc.date.issued
2022-12
dc.identifier.citation
Perdomo González, Davinia Isabel; Laseca, Nora; Demyda-peyrás, Sebastian; Valera, Mercedes; Cervantes, Isabel; et al.; Fine-tuning genomic and pedigree inbreeding rates in equine population with a deep and reliable stud book: the case of the Pura Raza Española horse; BioMed Central; Journal of Animal Science and Biotechnology; 13; 1; 12-2022; 1-14
dc.identifier.issn
1674-9782
dc.identifier.uri
http://hdl.handle.net/11336/201936
dc.description.abstract
Background: Estimating inbreeding, which is omnipresent and inevitable in livestock populations, is a primary goal for management and animal breeding especially for those interested in mitigating the negative consequences of inbreeding. Inbreeding coefficients have been historically estimated by using pedigree information; however, over the last decade, genome-base inbreeding coefficients have come to the forefront in this field. The Pura Raza Española (PRE) horse is an autochthonous Spanish horse breed which has been recognised since 1912. The total PRE population (344,718 horses) was used to estimate Classical (F), Ballou’s ancestral, Kalinowski’s ancestral, Kalinowski’s new and the ancestral history coefficient values. In addition, genotypic data from a selected population of 805 PRE individuals was used to determine the individual inbreeding coefficient using SNP-by-SNP-based techniques (methods of moments -FHOM-, the diagonal elements of the genomic -FG-, and hybrid matrixes -FH-) and ROH measures (FRZ). The analyse of both pedigree and genomic based inbreeding coefficients in a large and robust population such as the PRE horse, with proven parenteral information for the last 40 years and a high degree of completeness (over 90% for the last 70 years) will allow us to understand PRE genetic variability better and the correlations between the estimations will give the data greater reliability. Results: The mean values of the pedigree-based inbreeding coefficients ranged from 0.01 (F for the last 3 generations -F3-) to 0.44 (ancestral history coefficient) and the mean values of genomic-based inbreeding coefficients varied from 0.05 (FRZ for three generations, FH and FHOM) to 0.11 (FRZ for nine generations). Significant correlations were also found between pedigree and genomic inbreeding values, which ranged between 0.58 (F3 with FHOM) and 0.79 (F with FRZ). In addition, the correlations between FRZ estimated for the last 20 generations and the pedigree-based inbreeding highlight the fact that fewer generations of genomic data are required when comparing total inbreeding values, and the opposite when ancient values are calculated. Conclusions: Ultimately, our results show that it is still useful to work with a deep and reliable pedigree in pedigree-based genetic studies with very large effective population sizes. Obtaining a satisfactory parameter will always be desirable, but the approximation obtained with a robust pedigree will allow us to work more efficiently and economically than with massive genotyping.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
GENOMIC INBREEDING
dc.subject
HORSES
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PEDIGREE INBREEDING
dc.subject.classification
Tecnología GM, clonación de ganado, selección asistida, diagnósticos, tecnología de producción de biomasa, etc.
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Biotecnología Agropecuaria
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CIENCIAS AGRÍCOLAS
dc.title
Fine-tuning genomic and pedigree inbreeding rates in equine population with a deep and reliable stud book: the case of the Pura Raza Española horse
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-06-29T13:13:50Z
dc.identifier.eissn
2049-1891
dc.journal.volume
13
dc.journal.number
1
dc.journal.pagination
1-14
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Perdomo González, Davinia Isabel. Universidad de Sevilla; España
dc.description.fil
Fil: Laseca, Nora. Universidad de Córdoba; España
dc.description.fil
Fil: Demyda-peyrás, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Valera, Mercedes. Universidad de Sevilla; España
dc.description.fil
Fil: Cervantes, Isabel. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Molina, Antonio. Universidad de Córdoba; España
dc.journal.title
Journal of Animal Science and Biotechnology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/s40104-022-00781-5
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