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dc.contributor.author
Castillo Torres, Sergio A.
dc.contributor.author
Viti, María
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Martínez Villota, Viviana Alexandra
dc.contributor.author
Rossi, Malco Damian
dc.contributor.author
Merello, Marcelo Jorge
dc.date.available
2023-06-28T22:25:41Z
dc.date.issued
2022-07-19
dc.identifier.citation
Castillo Torres, Sergio A.; Viti, María; Martínez Villota, Viviana Alexandra; Rossi, Malco Damian; Merello, Marcelo Jorge; Multiple system atrophy laryngeal stridor treated with radiofrequency-assisted posterior cordotomy and arytenoidectomy; Dr. Dietrich Steinkopff Verlag; Clinical Autonomic Research; 32; 4; 19-7-2022; 303-306
dc.identifier.issn
0959-9851
dc.identifier.uri
http://hdl.handle.net/11336/201759
dc.description.abstract
Stridor is a harsh, high-pitched breathing sound caused by the rapid and turbulent airfow through a narrow airway. In patients with multiple system atrophy (MSA), stridor represents a supportive feature for clinical diagnosis and a prognostic marker when present during wakefulness and associated with bilateral vocal fold immobility (BVFI), due to the risk of upper airway obstruction and sudden death during sleep [1]. Current treatment recommendations when continuous positive airway pressure (CPAP) ventilation is inefective are limited to tracheostomy [1]. However, there is a scarcity of less-invasive alternatives for functionally independent patients who wish to avoid tracheostomy. Here we present a 55-year-old male patient with MSA who developed continuous stridor with dyspnea on exertion and was treated with posterior cordotomy and arytenoidectomy using radiofrequency (RF) through a microlaryngoscopic approach. The patient was diagnosed with MSA due to poorly levodopa-responsive Parkinsonism with onset at age 49 and an MDS-Unifed Parkinson’s Disease Rating Scale (MDS-UPDRS) III score of 48 points despite being under chronic levodopa therapy up to 1000 mg/day. At age 51, he developed urogenital failure, with erectile dysfunction, urinary urgency, and incomplete voiding, that at age 53 was followed by urinary incontinence requiring intermittent catheterization. On diagnostic assessment, brain magnetic resonance imaging (MRI) showed slight putaminal atrophy with an incomplete hyperintense lateral rim, an orthostatic stress test revealed nonsymptomatic neurogenic orthostatic hypotension, and a whole exome sequencing test revealed a variant of uncertain signifcance (VUS) in the LRRK2 gene (LRRK2 c.4536+3A>G, ClinVar: RCV000873745.6) that was interpreted as unrelated to the diagnosis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Dr. Dietrich Steinkopff Verlag
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MULTIPLE SYSTEM ATROPHY
dc.subject
POSTERIOR CORDOTOMY
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RADIOFREQUENCY
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STRIDOR
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Neurología Clínica
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Multiple system atrophy laryngeal stridor treated with radiofrequency-assisted posterior cordotomy and arytenoidectomy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-06-22T13:38:02Z
dc.identifier.eissn
1619-1560
dc.journal.volume
32
dc.journal.number
4
dc.journal.pagination
303-306
dc.journal.pais
Alemania
dc.description.fil
Fil: Castillo Torres, Sergio A.. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea". Servicio de Neurología Cognitiva, Neuropsiquiatría y Neuropsicología; Argentina
dc.description.fil
Fil: Viti, María. Centro de Educaciones Médicas e Investigación Clínica "Norberto Quirno"; Argentina
dc.description.fil
Fil: Martínez Villota, Viviana Alexandra. Fundación para la Lucha Contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea". Servicio de Neurología Cognitiva, Neuropsiquiatría y Neuropsicología; Argentina
dc.description.fil
Fil: Rossi, Malco Damian. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
dc.description.fil
Fil: Merello, Marcelo Jorge. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
dc.journal.title
Clinical Autonomic Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s10286-022-00876-z
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10286-022-00876-z
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