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dc.contributor.author
Ramirez, Maria de Los Angeles
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dc.contributor.author
Bindini, Elisa
dc.contributor.author
Moretti, Paolo
dc.contributor.author
Soler Illia, Galo Juan de Avila Arturo
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dc.contributor.author
Amenitsch, Heinz
dc.contributor.author
Andreozzi, Patrizia
dc.contributor.author
Ortore, Maria Grazia
dc.contributor.author
Moya, Sergio E.
dc.date.available
2023-06-28T17:16:03Z
dc.date.issued
2022-11
dc.identifier.citation
Ramirez, Maria de Los Angeles; Bindini, Elisa; Moretti, Paolo; Soler Illia, Galo Juan de Avila Arturo; Amenitsch, Heinz; et al.; Impact of PEGylation on the degradation and pore organization in mesoporous silica nanoparticles: A study of the inner mesoporous structure in physiologically relevant ionic conditions; Elsevier Science; Colloids and Surfaces B: Biointerfaces; 219; 11-2022; 1-9
dc.identifier.issn
0927-7765
dc.identifier.uri
http://hdl.handle.net/11336/201701
dc.description.abstract
The degradation of mesoporous silica nanoparticles (MSNs) in the biological milieu due to silica hydrolysis plays a fundamental role for the delivery of encapsulated drugs and therapeutics. However, little is known on the evolution of the pore arrangement in the MSNs in biologically relevant conditions. Small Angle X-ray scattering (SAXS) studies were performed on unmodified and PEGylated MSNs with a MCM-48 pore structure and average sizes of 140 nm, exposed to simulated body fluid solution (SBF) at pH 7.4 for different time intervals from 30 min to 24 h. Experiments were performed with silica concentrations below, at and over 0.14 mg/mL, the saturation concentration of silica in water at physiological temperature. At silica concentrations of 1 mg/mL (oversaturation), unmodified MSNs show variation in interpore distances over 6 h exposure to SBF, remaining constant thereafter. A decrease in radius of gyration is observed over the same time. Mesoporosity and radius of gyration of unmodified MSNs remain then unchanged up to 24 h. PEGylated MSNs at 1 mg/mL concentration show a broader diffraction peak but no change in the position of the peak is observed following 24 h exposure to SBF. PEGylated MSNs at 0.01 mg/mL show no diffraction peaks already after 30 min exposure to SBF, while at 0.14 mg/mL a small diffraction peak is present after 30 min exposure but disappears after 1 h.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DEGRADATION
dc.subject
MESOPOROUS SILICA NANOPARTICLES
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PEGYLATION
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SAXS
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SIMULATED BODY FLUID
dc.subject.classification
Otras Nanotecnología
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dc.subject.classification
Nanotecnología
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Impact of PEGylation on the degradation and pore organization in mesoporous silica nanoparticles: A study of the inner mesoporous structure in physiologically relevant ionic conditions
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-06-26T16:16:33Z
dc.journal.volume
219
dc.journal.pagination
1-9
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Ramirez, Maria de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Basque Research and Technology Alliance. CIC biomaGUNE; España
dc.description.fil
Fil: Bindini, Elisa. Basque Research and Technology Alliance. CIC biomaGUNE; España
dc.description.fil
Fil: Moretti, Paolo. Università Politecnica Delle Marche; Italia
dc.description.fil
Fil: Soler Illia, Galo Juan de Avila Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina
dc.description.fil
Fil: Amenitsch, Heinz. Graz University Of Technology.; Austria
dc.description.fil
Fil: Andreozzi, Patrizia. Università degli Studi di Firenze; Italia. Basque Research and Technology Alliance. CIC biomaGUNE; España
dc.description.fil
Fil: Ortore, Maria Grazia. Università Politecnica Delle Marche; Italia
dc.description.fil
Fil: Moya, Sergio E.. Basque Research and Technology Alliance. CIC biomaGUNE; España
dc.journal.title
Colloids and Surfaces B: Biointerfaces
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0927776522004805
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.colsurfb.2022.112797
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