Artículo
Multilocus sequence typing of Treponema pallidum pallidum in children with acquired syphilis by nonsexual contact
García, Luciana Noemí
; Morando, Nicolás
; Otero, Alejandro Adrián; Moroni, Samanta; Moscatelli, Guillermo
; Gonzalez, Nicolás; D Slojan, Alejandra; Lascano, María Fernanda
; Ballering, Griselda Edith; Pando, María de los Ángeles
; Altcheh, Jaime Marcelo
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Fecha de publicación:
11/2022
Editorial:
Future Medicine
Revista:
Future Microbiology
ISSN:
1746-0913
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background: There are scarce data of Treponema pallidum subsp. pallidum (TPA) characterization in children with syphilis. Nonsexually acquired transmission (NSAT) of TPA is possible in infants through close contact. Methods: A descriptive study in five families with NSAT of syphilis was conducted. Polymerase chain reaction detection of TPA in pediatric index cases (n = 6) and their relatives (n = 44) were conducted followed by multilocus sequence typing (MLST). Results: TPA was detected in swab samples in 16 cases and 12 were characterized by MLST. Nichols lineage was identified in two of five families and SS14-lineage in three of five. In four families, MLST profiles linked index cases to relatives. Conclusion: This is the first report of TPA characterization in children infected by NSAT. Plain language summary Syphilis is a disease caused by the bacterium Treponema pallidum subsp. pallidum (TPA). Although it is considered a sexually transmitted disease, syphilis can also be transmitted by nonsexual close contact with active lesions. There are clinical reports of this route of transmissions in children; however, there are no molecular characterizations of TPA in this population. A multidisciplinary study (epidemiological, clinical, social and molecular) was performed in six children from five families with clinical diagnosis of nonsexually transmitted syphilis. As a result, 18 infected persons were detected. In 16 individuals the presence of the bacterium genetic material was confirmed by molecular biology techniques, and in 12, its strain was analyzed. When we compared the data, we observed that in four families, the child's strain coincided with the one found in close contact, while in one family, this could not be determined. To our knowledge, this is the first report of TPA characterization in children, which underscore the importance of including molecular biology techniques in complex clinical scenarios such as these.
Palabras clave:
INFANTS
,
INFECTIOUS LESIONS
,
MOLECULAR TYPING
,
SYPHILIS
,
VARIANT
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Articulos(IMIPP)
Articulos de INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES EN PATOLOGIAS PEDIATRICAS
Articulos de INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES EN PATOLOGIAS PEDIATRICAS
Articulos(INBIRS)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Citación
García, Luciana Noemí; Morando, Nicolás; Otero, Alejandro Adrián; Moroni, Samanta; Moscatelli, Guillermo; et al.; Multilocus sequence typing of Treponema pallidum pallidum in children with acquired syphilis by nonsexual contact; Future Medicine; Future Microbiology; 17; 16; 11-2022; 1295-1305
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