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dc.contributor.author
Casey, Eric  
dc.contributor.author
Avale, Maria Elena  
dc.contributor.author
Kravitz, Alexxai  
dc.contributor.author
Rubinstein, Marcelo  
dc.date.available
2023-06-26T11:02:22Z  
dc.date.issued
2022-02-24  
dc.identifier.citation
Casey, Eric; Avale, Maria Elena; Kravitz, Alexxai; Rubinstein, Marcelo; Partial ablation of postsynaptic dopamine D2 receptors in the central nucleus of the amygdala increases risk avoidance in exploratory tasks; Society for Neuroscience; eNeuro; 9; 2; 24-2-2022; 1-12  
dc.identifier.uri
http://hdl.handle.net/11336/201406  
dc.description.abstract
The central nucleus of the amygdala (CeA) is involved in the expression of fear and has been implicated in several anxiety disorders. This structure is densely innervated by DAergic projections that impinge on amygdalar neurons expressing various dopamine (DA) receptor subtypes, including D2 receptors (D2Rs). Although various pharmacological approaches have assessed the role of D2Rs in the CeA, the actual participation of postsynaptic D2Rs in the CeA to defensive behaviors remains unclear. Here, we investigated the distribution of D2Rs in the CeA and their role in modifying neuronal activity and fear related behaviors in mice. First, using the mouse reporter strain D2R-EGFP, we verified that D2Rs are present both in neurons of the CeA and in A10 dorsocaudal (A10dc) DAergic neurons that innervate the CeA. Moreover, we showed that pharmacological stimulation of D2Rs increases the activity of protein kinase C (PKC)δ cells present in the CeA, a type of neuron previously associated with reduced defensive behaviors. Finally, using a molecular genetics approach that discriminates postsynaptic D2Rs from presynaptic D2 autoreceptors, we demonstrated that mice carrying targeted deletions of postsynaptic D2Rs in the CeA display increased risk avoidance in exploratory tasks. Together, our results indicate that postsynaptic D2Rs in the CeA attenuate behavioral reactions to potential environmental threats.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Society for Neuroscience  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
AMIGDALA  
dc.subject
DOPAMINA  
dc.subject
RECEPTOR D2  
dc.subject
LENTIVIRUS  
dc.subject.classification
Bioquímica y Biología Molecular  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Partial ablation of postsynaptic dopamine D2 receptors in the central nucleus of the amygdala increases risk avoidance in exploratory tasks  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-06-22T10:21:48Z  
dc.identifier.eissn
2373-2822  
dc.journal.volume
9  
dc.journal.number
2  
dc.journal.pagination
1-12  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Washington  
dc.description.fil
Fil: Casey, Eric. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Washington University in St. Louis; Estados Unidos  
dc.description.fil
Fil: Avale, Maria Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina  
dc.description.fil
Fil: Kravitz, Alexxai. Washington University in St. Louis; Estados Unidos  
dc.description.fil
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina  
dc.journal.title
eNeuro  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.eneuro.org/lookup/doi/10.1523/ENEURO.0528-21.2022  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1523/ENEURO.0528-21.2022