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dc.contributor.author
Carbo, Martin
dc.contributor.author
Molina, Victor Alejandro
dc.contributor.author
Pedreira, Maria Eugenia
dc.date.available
2017-07-11T19:13:26Z
dc.date.issued
2013-11
dc.identifier.citation
Carbo, Martin; Molina, Victor Alejandro; Pedreira, Maria Eugenia; The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata; Wiley; European Journal Of Neuroscience; 38; 9; 11-2013; 3302-3313
dc.identifier.issn
0953-816X
dc.identifier.uri
http://hdl.handle.net/11336/20138
dc.description.abstract
There is growing interest in the neurobiological mechanisms involved in the extinction of aversive memory. This cognitive process usually occurs after repeated or prolonged presentation of a conditioned stimulus that was previously associated with an unconditioned stimulus. If extinction is considered to be a new memory, the role of the γ-aminobutyric acid system (GABAergic system) during extinction memory consolidation should be similar to that described for the original trace. It is also accepted that negative modulation of the GABAergic system before testing can impair extinction memory expression. However, it seems possible to speculate that inhibitory mechanisms may be required in order to acquire a memory that is inhibitory in nature. Using a combination of behavioral protocols, such as weak and robust extinction training procedures, and pharmacological treatments, such as the systemic administration of GABAA agonist (muscimol) and antagonist (bicuculline), we investigated the role of the GABAergic system in the different phases of the extinction memory in the crab Neohelice granulata. We show that the stimulation of the GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse aspects of the extinction memory.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Gaba
dc.subject
Extincion
dc.subject
Condicionamiento Contextual Pavloviano
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Neohelice Granulata
dc.subject.classification
Otros Tópicos Biológicos
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-11T13:24:33Z
dc.journal.volume
38
dc.journal.number
9
dc.journal.pagination
3302-3313
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Carbo, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: Molina, Victor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil
Fil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.journal.title
European Journal Of Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/ejn.12328
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/ejn.12328/abstract


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