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dc.contributor.author
Altcheh, Jaime Marcelo
dc.contributor.author
Carosella, Mabel V.
dc.contributor.author
Ceballos, Ana
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D'Andrea, Ulises
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Jofre, Sandra M.
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Marotta, Carolina
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Mugeri, Domingo
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Sabbaj, Liliana
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Soto, Adriana
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Josse, Constant
dc.contributor.author
Montestruc, Francois
dc.contributor.author
McFarland, Lynne V.
dc.date.available
2023-06-26T10:23:53Z
dc.date.issued
2022-09
dc.identifier.citation
Altcheh, Jaime Marcelo; Carosella, Mabel V.; Ceballos, Ana; D'Andrea, Ulises; Jofre, Sandra M.; et al.; Randomized, direct comparison study of Saccharomyces boulardii CNCM I-745 versus multi-strained Bacillus clausii probiotics for the treatment of pediatric acute gastroenteritis; Lippincott Williams; Medicine; 101; 36; 9-2022; 1-8
dc.identifier.issn
0025-7974
dc.identifier.uri
http://hdl.handle.net/11336/201388
dc.description.abstract
Background: The choice of an appropriate probiotic for pediatric acute gastroenteritis (PAGE) can be confusing. Our aim was to compare the efficacy and safety of 2 probiotics (Saccharomyces boulardii CNCM I-745 vs a 4-strain mixture of Bacillus clausii O/C, SIN, N/R, T) for the treatment of PAGE. Methods: A 2-arm parallel, randomized trial recruited children (6 months to 5 years old) with mild-moderate acute diarrhea, from 8 centers in Argentina. A total of 317 children were enrolled and blindly randomized to 5 days of either S boulardii CNCM I-745 (n = 159) or a 4-strain mixture of B clausii (n = 158), then followed for 7 days post-probiotic treatment. A stool sample was collected at inclusion for pathogen identification. The primary outcome was duration of diarrhea defined as the time from enrollment to the last loose stool followed by the first 24-hour period with stool consistency improvement. Secondary outcomes included frequency of loose stools/day, severity of diarrhea, number reporting no diarrhea at Day 6, time-to-first formed stool, recurrence of diarrhea by study end (Day 12) and safety outcomes. Results: Three hundred twelve (98%) children completed the study. S boulardii CNCM I-745 showed a significant reduction (P =.04) in the mean duration of diarrhea (64.6 hours, 95% confidence interval [CI] 56.5-72.8) compared to those given B clausii (78.0 hours, 95% CI 69.9-86.1). Both probiotics showed improvement in secondary outcomes and were well-tolerated. Conclusion: In this study, S boulardii CNCM I-745 demonstrated better efficacy than B clausii mix for reducing the duration of pediatric acute diarrhea.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
BACILLUS CLAUSII
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DIARRHEA
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GASTROENTERITIS
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PROBIOTICS
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SACCHAROMYCES BOULARDII
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Nutrición, Dietética
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Randomized, direct comparison study of Saccharomyces boulardii CNCM I-745 versus multi-strained Bacillus clausii probiotics for the treatment of pediatric acute gastroenteritis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-06-14T10:11:47Z
dc.journal.volume
101
dc.journal.number
36
dc.journal.pagination
1-8
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Altcheh, Jaime Marcelo. Gobierno de la Ciudad de Buenos Aires. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas; Argentina
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Fil: Carosella, Mabel V.. No especifíca;
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Fil: Ceballos, Ana. Instituto Médico Río Cuarto; Argentina
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Fil: D'Andrea, Ulises. Instituto Médico Río Cuarto; Argentina
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Fil: Jofre, Sandra M.. No especifíca;
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Fil: Marotta, Carolina. No especifíca;
dc.description.fil
Fil: Mugeri, Domingo. No especifíca;
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Fil: Sabbaj, Liliana. No especifíca;
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Fil: Soto, Adriana. No especifíca;
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Fil: Josse, Constant. No especifíca;
dc.description.fil
Fil: Montestruc, Francois. No especifíca;
dc.description.fil
Fil: McFarland, Lynne V.. No especifíca;
dc.journal.title
Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1097/MD.0000000000030500
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/md-journal/Fulltext/2022/09090/Randomized,_direct_comparison_study_of.31.aspx
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